Predicting mortality in acute ischaemic stroke treated with mechanical thrombectomy: analysis of a multicentre prospective registry

Aren't you just so fucking glad research on predicting death is more important than research on recovery? I'd have choice words for the fuckers that approved this research. First would be: YOU'RE FIRED! The only goal in stroke is 100% recovery, this doesn't meet that goal and if you as a researcher don't see that you don't belong in stroke.

Predicting mortality in acute ischaemic stroke treated with mechanical thrombectomy: analysis of a multicentre prospective registry

1. Hao Li1,
2. http://orcid.org/0000-0003-4306-0460Shi-sheng Ye1,
3. Yuan-Ling Wu2,
4. Sheng-Ming Huang3,
5. Yong-Xin Li4,
6. Kui Lu5,
7. Jing-Bo Huang1,
8. Lve Chen4,
9. Hong-Zhuang Li4,
10. Wen-Jun Wu5,
11. Zhi-Lin Wu6,
12. Jian-Zhou Wu6,
13. Wang-Tao Zhong7,
14. Wen-Chuan Xian7,
15. Feng Liao7,
16. http://orcid.org/0000-0003-2097-8375Tao-Hsin Tung8,
17. Qiao-Ling Wu1,
18. Hai Chen1,
19. Li Yuan1,
20. Zhi Yang1,
21. Li-An Huang3

1. Correspondence to Dr Li-An Huang; huanglian1306@126.com

Abstract

Objectives We aimed to determine predictors of mortality within 90 days and develop a simple score for patients with mechanical thrombectomy (MT).

Design Analysis of a multicentre prospective registry.

Setting In six participating centres, patients who had an acute ischaemic stroke (AIS) treated by MT between March 2017 and May 2018 were documented prospectively.

Participants 224 patients with AIS were treated by MT.

Results Of 224 patients, 49 (21.9%) patients died, and 87 (38.8%) were independent. Variables associated with 90-day mortality were age, previous stroke, admission National Institutes of Health Stroke Scale (NIHSS), fasting blood glucose and occlusion site. Logistic regression identified four variables independently associated with 90-day mortality: age ≥80 years (OR 3.26, 95% CI 1.45 to 7.33), previous stroke (OR 2.33, 95% CI 1.04 to 5.21), admission NIHSS ≥18 (OR 2.37, 95% CI 1.13 to 4.99) and internal carotid artery or basilar artery occlusion (OR 2.92, 95% CI 1.34 to 6.40). Using these data, we developed predicting 90-day mortality of AIS with MT (PRACTICE) score ranging from 0 to 6 points. The receiver operator curve analysis found that PRACTICE score (area under the curve (AUC)=0.744, 95% CI 0.669 to 0.820) was numerically better than iScore (AUC=0.661, 95% CI 0.577 to 0.745) and Predicting Early Mortality of Ischemic Stroke score (AUC=0.638, 95% CI 0.551 to 0.725) for predicting 90-day mortality.

Conclusions We developed a simple score to estimate the 90-day mortality of patients who had an AIS treated with MT. But the score needs to be prospectively validated.

Trial registration number Chinese Clinical Trial Registry (ChiCTR-OOC-17013052).

Data availability statement

Data are available upon reasonable request. The data that support the findings of this study are available from the corresponding author upon reasonable request.

http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

http://dx.doi.org/10.1136/bmjopen-2020-043415