Meningeal lymphatics affect microglia responses and anti-Aβ(amyloid beta) immunotherapy

Since this is in mice your doctor and hospital will need to ensure human testing and creation of protocols that prevent the amyloid beta from accumulating. You need this because of this risk.

Dementia Risk Doubled in Patients Following Stroke September 2018

Maybe you want to see if this research also delivers VEGF-C  to the brain or you could ask your doctor about it:

Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivo

Your doctor should easily be able to get the protocol that delivered the VEGF-C to the mice and translate it to human delivery.

The latest here:

Meningeal lymphatics affect microglia responses and anti-Aβ(amyloid beta) immunotherapy

• Sandro Da Mesquita,
• Zachary Papadopoulos,
• […]
• Jonathan Kipnis 

Nature (2021)Cite this article

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Abstract

Alzheimer’s disease (AD) is the most prevalent cause of dementia¹. Although there is no effective treatment for AD, passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) is a promising therapeutic strategy^2,3. Meningeal lymphatic drainage has an important role in the accumulation of Aβ in the brain⁴, but it is not known whether modulation of meningeal lymphatic function can influence the outcome of immunotherapy in AD. Here we show that ablation of meningeal lymphatic vessels in 5xFAD mice (a mouse model of amyloid deposition that expresses five mutations found in familial AD) worsened the outcome of mice treated with anti-Aβ passive immunotherapy by exacerbating the deposition of Aβ, microgliosis, neurovascular dysfunction, and behavioural deficits. By contrast, therapeutic delivery of vascular endothelial growth factor C improved clearance of Aβ by monoclonal antibodies. Notably, there was a substantial overlap between the gene signature of microglia from 5xFAD mice with impaired meningeal lymphatic function and the transcriptional profile of activated microglia from the brains of individuals with AD. Overall, our data demonstrate that impaired meningeal lymphatic drainage exacerbates the microglial inflammatory response in AD and that enhancement of meningeal lymphatic function combined with immunotherapies could lead to better clinical outcomes.

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