Abbreviated Brain Care Score Predicts Dementia, Stroke, Depression Risk

 

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Brain Care Score (6 posts to July 2024)

Abbreviated Brain Care Score Predicts Dementia, Stroke, Depression Risk

An abbreviated version of the Brain Care Score, omitting physical measures, correlated with the full scale and significantly predicted risk for stroke, dementia, and late-life depression. An abbreviated version of the Brain Care Score (BCS) predicts dementia, stroke, and late-life depression risk, according to results of a study published in Neurology Open Access. The Brain Care Score is a validated, self-administered 21-point scale designed to estimate risk for dementia, stroke, and late-life depression based on modifiable physical, lifestyle, and social-emotional factors. Because the full BCS includes physical measures requiring blood collection, its use may be limited in some clinical or community settings Researchers from the University of Alabama at Birmingham and Massachusetts General Hospital analyzed data from the United Kingdom Biobank. Adults (N=397,515) aged 40 to 69 years who provided baseline data between 2006 and 2010 were assessed using both the full BCS and an abbreviated version comprising only 7 lifestyle and social-emotional components. Associations between BCS category and incident dementia, stroke, and late-life depression were evaluated over follow-up.

 

Our findings show that remote assessment of brain care has the potential to serve communities lacking traditional health care access.

The study population was 54% women, with a mean (SD) age of 56.4 (8.1) years, and was predominantly White (94%). Classification by the abbreviated BCS correlated strongly with the full BCS (Pearson r =0.70; Spearman r =0.66; both P <.001).

At a median follow-up of 13.2 years, 2.1% of participants had a stroke, 1.6% developed incident dementia, and 3.1% experienced late-life depression.

Compared with individuals categorized as low risk, those with medium and high BCS scores demonstrated lower risk for all outcomes using both the original and abbreviated instruments. For stroke, medium BCS scores were associated with adjusted hazard ratios (aHRs) of 0.68 with the full BCS and 0.75 with the abbreviated BCS, while high scores were associated with aHRs of 0.55 and 0.76, respectively. For dementia, medium BCS scores were associated with aHRs of 0.86 (full) and 0.80 (abbreviated), and high scores with aHRs of 0.87 and 0.92. For late-life depression, medium BCS scores were associated with aHRs of 0.65 (full) and 0.61 (abbreviated), and high scores with aHRs of 0.55 for both versions.

In age-stratified analyses, the abbreviated BCS did not reach statistical significance for predicting dementia among individuals younger than 50 years (aHR, 0.63; 95% CI, 0.36-1.09) or those aged 50 to 59 years (aHR, 0.95; 95% CI, 0.76-1.17), whereas the full BCS remained significantly associated with reduced dementia risk in these groups. Among participants aged 60 years or older, neither the full nor the abbreviated BCS was significantly associated with dementia risk relative to low BCS. Study limitations include the lack of racial and ethnic diversity in the cohort. The study authors concluded, “Omitting the physical components, we found that higher scores on the abbreviated version of the BCS well predicted protection against these disorders, although with less precision than the full BCS. Our findings show that remote assessment of brain care has the potential to serve communities lacking traditional health care access.” Disclosures: Some study authors declared affiliations with biotech, pharmaceutical, and/or device companies. Please see the original reference for a full list of authors’ disclosures. 

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