Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, August 10, 2025

Antidepressant-Like Effect of Saffron (Crocus sativus L.) in Mice Exposed to Chronic Unpredictable Mild Stress via Attenuating Neuroinflammation and Recovering Neuroplasticity

 

I'm sure your competent? doctor never got further research going on saffron almost a decade ago, right? Oh NO, you DON'T have a functioning stroke doctor, do you? Well, so what, they are still getting paid while being incompetent. Until we get pay for performance our doctors will never improve!
  • saffron (10 posts to January 2017)

    • Antidepressant-Like Effect of Saffron (Crocus sativus L.) in Mice Exposed to Chronic Unpredictable Mild Stress via Attenuating Neuroinflammation and Recovering Neuroplasticity


    Jiexin Zhou 1, Yuemei Hu 2, Pu Jing 1
    Affiliations 

    Abstract

    Saffron (Crocus sativus L.), a traditional food coloring and flavoring ingredient, has shown potential antidepressant activity in several preclinical and clinical studies. This study investigated the antidepressant effect and underlying mechanism of saffron extract (SE) using a chronic unpredictable mild stress (CUMS)-induced depressive mouse model. Mice subjected to 8-week CUMS were orally administered with SE or positive medicine fluoxetine for 6 weeks. Behavioral tests, histopathological analysis, proinflammatory cytokine levels, and protein/mRNA expression were evaluated to characterize the antidepressant effects of SE. Results showed SE improved depression-like behaviors, ameliorated hippocampal and neuronal damage, remitted neuroinflammation, and restored neuroplasticity in mice. The antineuroinflammatory effect of SE may be attributed to inhibition of microglial activation, NF-κB signaling pathway, and proinflammatory cytokines' secretion. In addition, the upregulation of hippocampal Creb, Bdnf, and Trkb, and related proteins by SE treatment may be a mechanism for neuroplasticity recovery. These results demonstrated the antidepressant effects of SE in a CUMS-induced depressive model and manifested the potential of saffron as a functional food for relieving depression.

    Keywords: depression‐like behavior; hippocampus; microglia; neural plasticity; neuroinflammation.

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