Is there ANYONE IN STROKE THAT WILL FOLOWUP this with research to help stroke survivors? NO? So, EVERYONE IN STROKE IS FUCKING INCOMPETENT?
Send me personal hate mail on this: oc1dean@gmail.com. I'll print your complete statement with your name(If you can't stand by your name don't bother replying anonymously) and my response in my blog. Or are you afraid to engage with my stroke-addled mind? No excuses are allowed! You're medically trained; it should be simple to precisely state EXACTLY WHY you were trained to be incompetent with NO EXCUSES!
I take no prisoners in trying to get stroke solved! No knowledge of all of this and you have blithering idiots in charge, how long before you fire all of them?
The latest here:
Structured lifestyle intervention linked to improved blood regulation in brain, heart
Key takeaways:
- The structured intervention had greater impact in men than women.
- The structured intervention also showed greater improvement for those aged 70 years and older vs. those younger than 70 years.
Older adults who adhered to a structured lifestyle intervention saw greater improvement from blood flow and regulation mechanisms in both the brain and heart at 2 years than those who used a self-guided intervention, , data show.
“Multiple lines of evidence highlight the importance of vascular contributions to cognitive impairment and dementia,” Tina Brinkley, PhD, associate professor of gerontology and geriatrics, internal medicine at Wake Forest University School of Medicine, told Healio about the updated research from the POINTER study presented at CTAD.
“While most of this research is focused on vascular pathology found in the brain (which is) detectable on an MRI or PET scan, systemic or peripheral measures that reflect the health of blood vessels throughout the body and how well these vessels communicate with the brain is also very important,” she said.
As cardiovascular health plays an integral role in overall health in older adults, Brinkley and colleagues sought to investigate the neurovascular mechanisms that underlie intended effects of lifestyle interventions.
The POINTER-NV neurovascular ancillary study examined 491 individuals from the parent POINTER study without atrial fibrillation or a pacemaker at baseline (mean age, 68.1 years; 61% women) and randomly assigned them on a 1:1 basis to either the structured lifestyle intervention including a rigorous schedule of diet and exercise (n = 246; mean age, 68.1 years; 58% women) or a self-guided intervention (n = 245; mean age, 68.2 years; 65% women).
Neurovascular assessments, which included heart rate variability, aortic function and carotid arterial flow, were performed at baseline, 12 months and 24 months.
The primary outcome for POINTER-NV was average change from baseline of baroreflex sensitivity (expressed as milliseconds per millimeters of Mercury[ms/mmHg]), with secondary outcomes including measurements of blood flow in the heart and brain, autonomic function as well as structural and functional measurements in the heart and brain.
Covariates for analysis were baseline age, sex and race.
According to results, those assigned to the structured lifestyle intervention recorded a mean change in baroreflex sensitivity of 1.177 ms/mmHg (95% CI: 0.634-1.72) from baseline to 2 years, while those in the self-guided intervention group recorded a mean change in that same interval of 0.291 ms/mmHg (95% CI: -0.246-0.828).
The mean adjusted difference between the structured vs. self-guided interventions was also significantly higher for men (1.921 vs. 0.337) and those aged 70 years or older (1.893 vs. 0.213) compared with that for women (0.606 vs. 0.265) and those aged younger than 70 years (0.699 vs. 0.349)
The researchers additionally reported the mean comparative changes from baseline to 2 years in structured vs. self-guided interventions:
- heart rate variability (2.633; 95% CI: 0.915-4.352);
- aortic pulse wave velocity (-1.912; 95% CI: -3.488 to -0.336); and
- carotid transmission coefficient (-0.014; 95% CI: -0.025 to -0.004).
All indicated positive effects for the structured intervention, Brinkley and colleagues wrote.
The comprehensive neurovascular assessment performed in POINTER-NV will be crucial for future clinical assessments and protocols through its identification of which measures of neurovascular health are most relevant to the patient population, she said.
“Collectively, these changes could protect the brain from excessive blood pressure and pulsatile blood flow, which negatively impact brain structure and function,” Brinkley told Healio. “In the long run, these benefits may help to preserve cognitive function and lower the risk for dementia in U.S. POINTER participants.”
For more information:
Tina Brinkley, PhD, can be reached at neurology@healio.com.
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