Deans' stroke musings: Abnormal functional connectivity density in patients with ischemic white matter lesions: An observational study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, October 2, 2016

Abnormal functional connectivity density in patients with ischemic white matter lesions: An observational study

So what if they cause cognitive problems? Fucking useless research with no solutions provided to fix those problems. I supposedly have a bunch of these although my doctor never showed me any scans.
http://www.mdlinx.com/internal-medicine/medical-news-article/2016/09/28/white-matter-lesions/6865315/?news_id=881&newsdt=100116&subspec_id=488&

Medicine, 09/28/2016Ding JR, et al.

In this observational study, authors produced new insights into how white matter lesions cause cognitive and motor decline from cortical functional connectivity perspective.

Methods

Researchers manipulated functional connectivity density mapping (FCDM) to analyze changes in brain functional connectivity in 16 patients with ischemic WMLs and 13 controls.
Both short– and long–range FCD maps were quantified, and group comparisons were conducted between the 2 groups.
They conducted a correlation analysis between regions with altered FCD and cognitive test scores (Mini–Mental State Examination [MMSE] and Montreal Cognitive Assessment [MoCA]) in the patient group.

Results

They observed that patients with ischemic WMLs exhibited reduced short–range FCD in the temporal cortex, primary motor cortex, and subcortical region, which could account for inadequate top–down attention, impaired motor, memory, and executive function associated with WMLs.
The positive correlation between primary motor cortex and MoCA scores yielded evidence for the influences of cognitive function on behavioral performance.
The inferior parietal cortex exhibited increased short–range FCD, reflecting a hyper bottom–up attention to compensate for the inadequate top–down attention for language comprehension and information retrieval in patients with WMLs.
Moreover, the prefrontal and primary motor cortex showed increased long–range FCD and the former positively correlated with MoCA scores, which recommended a strategy of cortical functional reorganization to compensate for motor and executive deficits.

Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report