Deans' stroke musings: Association between abnormal body weight and stroke outcome: A meta-analysis and systematic review

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, June 22, 2021

Association between abnormal body weight and stroke outcome: A meta-analysis and systematic review

But you don't tell us how well they recovered. Don't you think that might be important to know?

Association between abnormal body weight and stroke outcome: A meta-analysis and systematic review

Peng Zhang, Xiu-Li Yan, Yang Qu, Zhen-Ni Guo, Yi Yang

First published: 25 April 2021

https://doi.org/10.1111/ene.14881

Funding information

This project was supported by the National Key R&D Program of China (2016YFC1301600), JLUSTIRT (2017TD-12), and Science and Technology Department of Jilin province (20180623052TC). This project was also supported by the Youth Development Foundation of First Hospital of Jilin University (JDYY102019039).

Abstract

Background and purpose

To test the hypothesis that “obesity paradox” exists in stroke patients, we conducted a meta-analysis and systematic review on the association between abnormal body weight (obesity, overweight, or underweight) and the outcome of different types of stroke.

Methods

This meta-analysis and systematic review was performed in conformity to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines in Appendix S2. Studies investigating the association between abnormal body weight and the outcome of different types of stroke were searched for in the PubMed and Embase databases from their inception to 20 March 2021.

Results

Thirty-three articles including 84,660 patients were included in this study. Obesity and overweight were associated with longer survival in mixed-stroke patients (acute ischemic stroke [AIS] combined with one or more other stroke subtypes) than was normal weight, whereas underweight was related to shorter survival; the pooled hazard ratios (HRs) of mortality were 0.77 (95% confidence interval [CI] = 0.71–0.83) for obesity, 0.76 (95% CI = 0.72–0.80) for overweight, and 1.71 (95% CI = 1.56–1.87) for underweight. However, only obesity was associated with longer survival in AIS patients compared with normal weight, and underweight was related to shorter survival; the pooled HR of mortality was 0.75 (95% CI = 0.64–0.88) for obesity and 1.53 (95% CI = 1.27–1.85) for underweight. After merging mixed-stroke and AIS patients, we obtained similar results as in mixed-stroke patients.

Conclusions

Our results suggested that in patients with mixed stroke or AIS, obesity was associated with a longer survival time than normal weight, whereas underweight was associated with a shorter survival time.