Will you stop with this biomarker crapola. You ask the survivors a binary question. 'Are you 100% recovered? Y/N?' Then you deliver whatever protocols are needed to get to 100% recovery.
Muscle changes after stroke and their impact on recovery: Time for a paradigm shift? Review and commentary
Topics in Stroke Rehabilitation , Volume 28(2) , Pgs. 104-111. NARIC Accession Number: J86303. What's this? ISSN: 1074-9357. Author(s): Beckwée, David ; Lefeber, Nina ; Bautmans, Ivan ; Lotte Cuypers, ; De Keersmaecker, Emma; De Raedt, Sylvie ; Kerckhofs, Eric ; Nagels, Guy ; Njemini, Rose ; Perkisas, Stany ; Scheys, Ellen ; Swinnen, Eva. Publication Year: 2021. Number of Pages: 8.
Abstract:
This review was set out to shine new light on the debate of biomarkers in stroke rehabilitation by linking fundamental insights from biogerontological sciences to neurorehabilitation sciences. In particular, skeletal muscle changes and inflammation are addressed as two potential constructs from which biomarkers for stroke rehabilitation can be derived. Understanding the interplay between these constructs as well as their relationship to recovery could enhance stroke rehabilitation in the future. The rationale for the selection of these constructs is three-fold. First, recent stroke literature emphasizes the importance of identifying muscle wasting (also called stroke-induced muscle wasting) in stroke patients, a concept that is widely investigated in geriatrics but less in the stroke population. Second, insights from transdisciplinary research domains such as gerontology have shown that inflammation has severe catabolic effects on muscles, which may impede rehabilitation outcomes such as gait recovery. Last, it has been proven that high-intensity muscle strengthening exercises have strong anti-inflammatory effects in a non-stroke population. The findings emphasize the need for a paradigm shift in stroke rehabilitation research. The time course of muscle adaptions and inflammation should further be studied to develop optimal windows for treatment and strategies to optimize recovery post-stroke. Therefore, an evidence-based rationale is presented for developing research on individual changes of muscle and inflammation after a stroke. Descriptor Terms: BIOCHEMISTRY, IMMUNE SYSTEM DISORDERS, MUSCLES, MUSCULAR IMPAIRMENTS, REHABILITATION RESEARCH, RESEARCH REVIEWS, STROKE. Can this document be ordered through NARIC's document delivery service*?: Y. Citation: Beckwée, David , Lefeber, Nina , Bautmans, Ivan , Lotte Cuypers, , De Keersmaecker, Emma, De Raedt, Sylvie , Kerckhofs, Eric , Nagels, Guy , Njemini, Rose , Perkisas, Stany , Scheys, Ellen , Swinnen, Eva. (2021). Muscle changes after stroke and their impact on recovery: Time for a paradigm shift? Review and commentary. Topics in Stroke Rehabilitation , 28(2), Pgs. 104-111. Retrieved 6/22/2021, from REHABDATA database.
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