Evidence for a window of enhanced plasticity in the human motor cortex following ischemic stroke

Useless. We've known about neuoplasticity for decades. But we still have no understanding of why a neuron drops its' function and takes on a neighboring function. Since we don't know that we can't make neuroplastictity repeatable on demand. NO PROTOCOLS CAN BE WRITTEN ON NEUROPLASTICITY UNTIL WE KNOW THAT. We get useless guidelines instead.  Until we get exact protocols our stroke medical team can blame the survivor for not recovering. It's the best 'get out of jail free' card there is. Your stroke medical team has just pushed all responsibility for recovering off their backs and onto yours.

YOU have to put the monkey(responsibility for your recovery) on their back and never let them transfer it back to you. Tell them you know all about the Harvard Business Review article on monkey on the back tossing.

 Evidence for a window of enhanced plasticity in the human motor cortex following ischemic stroke

Neurorehabilitation and Neural Repair , Volume 35(4) , Pgs. 307-320.

NARIC Accession Number: J86353.  What's this?
ISSN: 1545-9683.
Author(s): Hordacre, Brenton ; Austin, Duncan ; Brown, Katlyn E. ; Graetz, Lynton ; Pareés, Isabel ; De Trane, Stefania ; Vallence, Ann-Maree ; Koblar, Simon ; Kleinig, Timothy ; McDonnell, Michelle N. ; Greenwood, Richard ; Ridding, Michael C. ; Rothwell, John C..
Publication Year: 2021.
Number of Pages: 14.

Abstract: 

Study measured synaptic plasticity at a neural level in human stroke survivors to test whether there is an early period of enhanced synaptic plasticity in the weeks and months after ischemic stroke. Continuous theta burst stimulation (cTBS) was used to activate synapses repeatedly in the motor cortex and initiate early stages of synaptic plasticity that temporarily reduces cortical excitability and motor-evoked potential amplitude. Thus, the greater the effect of cTBS on the motor-evoked potential, the greater the inferred level of synaptic plasticity. Data were collected from separate cohorts (Australia and United Kingdom). In each cohort, serial measurements were made in the weeks to months following stroke. Data were obtained for the ipsilesional motor cortex in 31 stroke survivors (Australia) over 12 months and the contralesional motor cortex in 29 stroke survivors (United Kingdom) over 6 months. Depression of cortical excitability by cTBS was most prominent shortly after stroke in the contralesional hemisphere and diminished over subsequent sessions. cTBS response did not differ across the 12-month follow-up period in the ipsilesional hemisphere. Results provide the first neurophysiological evidence consistent with a period of enhanced synaptic plasticity in the human brain after stroke. Behavioral training given during this period may be especially effective in supporting poststroke recovery.
Descriptor Terms: BODY MOVEMENT, BRAIN, ELECTRICAL STIMULATION, HEALTH PROMOTION, INTERNATIONAL REHABILITATION, LIMBS, MOTOR SKILLS, STROKE.


Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Hordacre, Brenton , Austin, Duncan , Brown, Katlyn E. , Graetz, Lynton , Pareés, Isabel , De Trane, Stefania , Vallence, Ann-Maree , Koblar, Simon , Kleinig, Timothy , McDonnell, Michelle N. , Greenwood, Richard , Ridding, Michael C. , Rothwell, John C.. (2021). Evidence for a window of enhanced plasticity in the human motor cortex following ischemic stroke.  Neurorehabilitation and Neural Repair , 35(4), Pgs. 307-320. Retrieved 6/22/2021, from REHABDATA database.