Deans' stroke musings: Calorie restriction conferred improvement effect on long-term rehabilitation of ischemic stroke via gut microbiota

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 17, 2021

Calorie restriction conferred improvement effect on long-term rehabilitation of ischemic stroke via gut microbiota

Now we need human testing which your doctors and stroke hospital will do nothing to initiate. This is in mice so don't ask your doctor to find and administer Bifidobacterium.

Yu-QinMao^a^b¹ BingHan^a^b Zheng-YanZhang^a^b Hui-LingChen^a^b Zhan-MingLi^a^b Chao-YueKong^a^b Jia-QiXu^a^b Pei-RanCai^a^b Yu-PengZeng^c JingZhao^d Yan-PingZhao^c Li-ShunWang^a^b

https://doi.org/10.1016/j.phrs.2021.105726 Get rights and content

Highlights

•: Calorie restriction greatly alters the composition of gut microbiota for mice to confer protective effects on ischemic stroke.
•: Calorie restriction greatly influences the holistic metabolism profile, which is associated with the rehabilitation.
•: Upshifting the abundance of Bifidobacterium enables to improve the rehabilitation of post-stroke mice.

Abstract

Calorie restriction can modulate the gut microbiota and protect against many diseases including ischemic stroke. However, the role of calorie-restriction-induced microbiota alteration remained unknown in ischemic stroke rehabilitation. Here we conducted 30% reduction of caloric intake on mice for four weeks, to evaluate its role on ischemic stroke rehabilitation. Significantly, this calorie restriction led to better long-term rehabilitation in comparison of normal control. Notably, the transplantation of gut microbiome from calorie-restriction-treated mice to post-stroke mice was eligible to obtain better long-term rehabilitation of stroke mice. Bifidobacterium identified by 16 S ribosomal RNA sequencing were enriched in those of calorie-restriction mice. Then we administrated Bifidobacterium to stroke mice and found Bifidobacterium treatment could successfully improve the long-term rehabilitation of cerebral ischemia mice. Furthermore, the metabolomics analysis revealed a panel of upshifting metabolites, suggesting that calorie restriction greatly altered the gut microbiota composition and its metabolism. Hence, we discovered the novel effect of CR on long-term rehabilitation of ischemic stroke and the underlying role of gut microbiota, which might provide novel thoughts for the clinical post-stroke rehabilitation.

Graphical Abstract

Calorie restriction confers protective effects on long-term rehabilitation of stroke, partly through gut microbiota modulation, especially by enrichment of Bifidobacterium.