Deans' stroke musings: Polyphenol consumption and neurodegeneration risk: A systematic meta-analysis of randomized controlled trials bridging nutrition and cognitive health

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, January 9, 2026

Polyphenol consumption and neurodegeneration risk: A systematic meta-analysis of randomized controlled trials bridging nutrition and cognitive health

Didn't your competent? doctor already create protocols for you on polyphenols? NO? So, totally fucking incompetent by not reading and implementing research? And the board of directors is no better?

polyphenols (30 posts to Septenber 2012)

Polyphenol consumption and neurodegeneration risk: A systematic meta-analysis of randomized controlled trials bridging nutrition and cognitive health

(Note: The full text of this document is currently only available in the PDF Version )

Xiaomei Wang , Jiao Yang , Jiayuan Zhang , Gaihong Yu , Jian Zhu and Yingli Nie

Received 26th November 2025 , Accepted 3rd January 2026

First published on 6th January 2026

Abstract

Given the potential of polyphenols to mitigate neurodegenerative diseases (NDDs), this meta-analysis investigated whether clinical evidence supports the use of polyphenols for neuroprotection and as nutritional strategies in NDDs. We analyzed 14 polyphenol types across seven NDDs. From 15,073 records identified in Embase, Cochrane Library, PubMed, and Web of Science, 13 studies involving 849 participants were included. Prespecified outcomes comprised global cognition (Mini-Mental State Examination, MMSE), domain-specific cognition (Alzheimer’s Disease Cooperative Study–Cognitive Subscale, ADCS-Cog), activities of daily living (Alzheimer’s Disease Cooperative Study–Activities of Daily Living, ADCS-ADL), neuropsychiatric symptoms (Neuropsychiatric Inventory, NPI), and selected biomarkers (plasma amyloid-β40 and brain-derived neurotrophic factor, BDNF). Reporting followed PRISMA 2020 guidelines, methods conformed to the Cochrane Handbook, and certainty of evidence was assessed using GRADE. Overall, polyphenol supplementation was associated with improved global cognition (pooled MD in MMSE = 2.06; 95% CI 0.62–3.49). In subgroup analyses, flavonoids were associated with a modest but significant improvement in MMSE scores, whereas stilbenes produced a significant benefit in daily functioning (ADCS-ADL) without clear gains in MMSE or ADCS-Cog and no consistent effects on NPI. Anthocyanidins, phenolic acids, and lignans did not significantly affect cognitive outcomes (MMSE or ADCS-Cog), and polyphenol subclasses did not yield robust or consistent changes in NPI or biomarker endpoints (Aβ40 and BDNF). Specific polyphenol subclasses therefore appear to confer selective cognitive and functional benefits, with stilbenes primarily supporting functional outcomes and flavonoids potentially enhancing global cognition.