Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Sunday, November 24, 2013

Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage

Is this another player in the neuronal cascade of death? To join the other four. Is your doctor going to come up with a research project to prove this hypothesis? If not, then who the hell will?
1.  glutamate poisoning
2.  excitotoxicity
3.  Capillaries that don't open due to pericytes
4.  Inflammatory action leaking through the blood brain barrier.
http://link.springer.com/article/10.1007/s12975-013-0301-2

Purchase on Springer.com

$39.95 / €34.95 / £29.95*
* Final gross prices may vary according to local VAT.
Get Access

Abstract

This is a speculative review of the role of the lysosome in ischemic cell death in the mammalian brain. In particular, it focuses on the role of the permeabilization of the lysosomal membrane to proteins (LMP) as a major mechanism of cell death in mild, but lethal, ischemic insults. The first section of the review outlines the evidence that this is the case, using the relatively few extant studies of mammalian brain. In the second section of the review, the mechanism by which an ischemic insult might lead to LMP is discussed. A metabolic sequence including NMDA receptor activation, activation of phospholipase A2 and production of free radicals, and also the activation of calpain are shown to be critical. The remainder of the section speculates on the actual agent(s) which may be causing the lysosomal membrane change, based on extensive literature references. There is currently no knowledge of the actual mechanism. The third section considers potential targets of the released lysosomal proteases and other proteins that might mediate the lethal effects of LMP, focusing largely on the mitochondria as the target. Again, this is speculative as the targets are not known. Finally, the fourth section addresses the level of importance that LMP has in the process of ischemic cell death and concludes that it may well play the major role during mild but lethal ischemic insults. This novel, so-called “lysosomocentric,” hypothesis is briefly critiqued. The therapeutic potential of this conclusion is then discussed.

2 comments:

  1. Dean, I think stroke survivors who read your blog aren't primarily interested in preventing damage to other people's brains; they're interested in recovering their abilities. For me, preventing the neuronal cascade of death is right there with the topic of stroke prevention - nothing to do with me. Selfish I am, I know, but I want legit research into recovery techniques; I want a recovery protocol, not platitudes like "Every blah, blah..." and "Never give up."

    ReplyDelete
    Replies
    1. I agree but what I am trying to do is get survivors to ask their doctor why there is nothing that would have prevented much of the damage in the first place. What you are asking for is effective stroke protocols which also don't exist. So much to do and no one doing anything.

      Delete