Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 22,618 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html
Sunday, November 24, 2013
Lysosomal Membrane Permeabilization as a Key Player in Brain Ischemic Cell Death: a “Lysosomocentric” Hypothesis for Ischemic Brain Damage
This is a speculative
review of the role of the lysosome in ischemic cell death in the
mammalian brain. In particular, it focuses on the role of the
permeabilization of the lysosomal membrane to proteins (LMP) as a major
mechanism of cell death in mild, but lethal, ischemic insults. The first
section of the review outlines the evidence that this is the case,
using the relatively few extant studies of mammalian brain. In the
second section of the review, the mechanism by which an ischemic insult
might lead to LMP is discussed. A metabolic sequence including NMDA
receptor activation, activation of phospholipase A2 and production of
free radicals, and also the activation of calpain are shown to be
critical. The remainder of the section speculates on the actual agent(s)
which may be causing the lysosomal membrane change, based on extensive
literature references. There is currently no knowledge of the actual
mechanism. The third section considers potential targets of the released
lysosomal proteases and other proteins that might mediate the lethal
effects of LMP, focusing largely on the mitochondria as the target.
Again, this is speculative as the targets are not known. Finally, the
fourth section addresses the level of importance that LMP has in the
process of ischemic cell death and concludes that it may well play the
major role during mild but lethal ischemic insults. This novel,
so-called “lysosomocentric,” hypothesis is briefly critiqued. The
therapeutic potential of this conclusion is then discussed.