Deans' stroke musings: Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, August 23, 2022

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

So you described something, but provided NOTHING that helps survivors recover. Useless.

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

Yuling Wang,

Ling Yang,

Yan Zhang and

Junyan Liu^*

Department of Neurology, Third Hospital of Hebei Medical University, Shijiazhuang, China

Aim: The aim of this study was to assess the relationship of circadian syndrome and stroke.

Methods: We performed a cross-sectional analysis of 11,855 participants from the National Health and Nutrition Examination Survey (NHANES) database between 2005 and 2018, and collected the baseline characteristics. Multivariate logistic regression models were developed to explore the association between circadian syndrome and stroke. Simultaneously, subgroup analyses based on the difference of gender, race, and components associated with circadian syndrome also were performed. The odds ratio (OR) and 95% CI were calculated in this study.

Results: All the participants were divided into the non-stroke group and the stroke group. There were approximately 3.48% patients exclusively with stroke and 19.03% patients exclusively with circadian syndrome in our study. The results suggested that the risk of stroke in patients with circadian syndrome was higher than that in patients without circadian syndrome (OR = 1.322, 95 CI%: 1.020–1.713). Similar associations were found in women with circadian syndrome (OR = 1.515, 95 CI%: 1.086–2.114), non-Hispanic whites with circadian syndrome (OR = 1.544, 95 CI%: 1.124–2.122), participants with circadian syndrome who had elevated waist circumference (OR = 1.395, 95 CI%: 1.070–1.819) or short sleep (OR = 1.763, 95 CI%: 1.033–3.009).

Conclusion: Circadian syndrome was associated with the risk of stroke. Particularly, we should pay more close attention to the risk of stroke in those populations who were female, non-Hispanic whites, had the symptoms of elevated waist circumference or short sleep.

Introduction

Stroke is the leading cause of mortality and serious long-term disability worldwide and has been considered one of the most prevalent and devastating diseases affecting humanity today (1, 2). According to the report of the Global Burden of Disease, the number of patients who were diagnosed with stroke has continued to increase in recent years, resulting in a significant economic burden (3). Existing evidence suggested the risk factors related to stroke, such as arterial hypertension, dyslipidemia, diabetes mellitus, obesity, sleep disorders (4, 5). A better understanding of the contribution of risk factors to stroke burden is important for effective prevention strategies.

The circadian system plays an important role in human health and metabolism (6). Some poor lifestyles, including sleep disturbances, the use of artificial light, and shift work, have been reported to cause the circadian rhythm disturbances, which have adverse effects on human health (7). Recently, a growing number of studies have focused on the relationship between the circadian system and chronic diseases (8–10). Circadian dysfunction has been proposed and defined as the presence of any four of the following seven traits, including elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein (HDL)-cholesterol, elevated blood pressure, elevated fasting glucose, short sleep duration (<6 h/day), and the depression symptom (7). Shi et al. (11) assessed the association between circadian syndrome and cardiovascular disease (CVD), and the result also suggested that the circadian syndrome was a strong predictor for CVD occurrence. However, to the best of our knowledge, there has been no study that examined the association between circadian syndrome and stroke so far.

Herein, the aim of this study was to explore the correlation between circadian syndrome and the occurrence of stroke, and focusing on the number of symptoms in circadian syndrome. In addition, we performed subgroup analyses based on gender, race, and components associated with circadian syndrome.