Exposure to static magnetic field facilitates selective attention and neuroplasticity in rats

 So human testing needed. Will never occur since we have NO leadership and NO strategy anywhere in stroke. You, your children and grandchildren are screwed until we get survivors in charge.

Exposure to static magnetic field facilitates selective attention and neuroplasticity in rats

Author links open overlay panelTingtingWang^aNasraYassin^aSalmanZubedat^bYelenaLoboda^aAviAvital^bLeviSchachter^cJohn P.M.Finberg^a

https://doi.org/10.1016/j.brainresbull.2022.08.016Get rights and content

Highlights

•

Static magnetic fields (SMF) have neuroprotective and behavioral effects in rats.

•

Six days exposure to SMF enhanced selective attention that attenuated after longer SMF.

•

SMF increased neuroplasticity-related structural protein levels in the rat brain.

•

Magnetoreceptor cryptochrome (CRY1) was expressed in several brain areas of rats.

•

Five days SMF exposure increased expression of CRY1 in the cortex and striatum.

Abstract

Static magnetic fields (SMF) have neuroprotective and behavioral effects in rats, however, little is known about the effects of SMF on cognition, motor function and the underlying neurochemical mechanisms. In this study, we focused on the effects of short-term (5~10d) and long-term (13~38d) SMF exposure on selective attention and motor coordination of rats, as well as associated alterations in expression level of neuroplasticity-related structural proteins and cryptochrome (CRY1) protein in the cortex, striatum and ventral midbrain. The results showed that 6 d SMF exposure significantly enhanced selective attention without affecting locomotor activity in open field. All SMF exposures non-significantly enhanced motor coordination (Rotarod test). Neurochemical analysis demonstrated that 5d SMF exposure increased the expression of cortical and striatal CRY1 and synapsin-1 (SYN1), striatal total synapsins (SYN), and synaptophysin (SYP), growth associated protein-43 (GAP43) and post-synaptic density protein-95 (PSD95) in the ventral midbrain. Exposure to SMF for 14d increased PSD95 level in the ventral midbrain while longer SMF exposure elevated the levels of PSD95 in the cortex, SYN and SYN1 in all the examined brain areas. The increased expression of cortical and striatal CRY1and SYN1 correlated with the short-lasting effect of SMF on improving selective attention. Collectively, SMF’s effect on selective attention attenuated following longer exposure to SMF whereas its effects on neuroplasticity-related structural biomarkers were time- and brain area-dependent, with some protein levels increasing with longer time exposure. These findings suggest a potential use of SMF for treatment of neurological diseases in which selective attention or neuroplasticity is impaired.

Keywords

static magnetic field

cryptochrome

neuroplasticity

cognition

synapsins

Data availability

Data will be made available on request.