Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 5, 2026

Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study

I hate research with motor evoked potentials. It tells us nothing about how to get to actual recovery. 

Cervicomedullary motor evoked responses in individuals with severe chronic hemiparesis post-stroke: a feasibility study


Carley L. P. ButlerCarley L. P. Butler1,2,3Aditya DuttAditya Dutt4Carolee WinsteinCarolee Winstein5Monica PerezMonica Perez1,2,3Mary Ellen StoykovMary Ellen Stoykov1,2*
  • 1Northwestern University, Evanston, United States
  • 2Shirley Ryan AbilityLab, Chicago, United States
  • 3Edward Hines Junior Veterans Affairs Hospital, Hines, United States
  • 4Chicago College of Osteopathic Medicine, Downers Grove, United States
  • 5University of Southern California Division of Biokinesiology and Physical Therapy, Los Angeles, United States

The final, formatted version of the article will be published soon.

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    Understanding the neural mechanisms underlying upper limb motor recovery after stroke remains a significant challenge in rehabilitation research. It has been proposed that individuals who show no motor-evoked potential (MEP) response to transcranial magnetic stimulation (TMS) and are thus classified as MEP negative (MEP-) have limited potential for recovery in part due to damage of the corticospinal pathway.(Well then, solve the problem of getting those people recovered! Isn't that what the fuck stroke research is for? Why the fuck aren't you trying for 100% recovery? 

    Laziness? Incompetence? Or just don't care? NO leadership? NO strategy? Not my job? Not my Problem!)

     In this study, we investigate how individuals categorized as MEP-with TMS respond to stimulation of the corticospinal pathway at a subcortical level. We describe the methodology for eliciting MEPs by using cervicomedullary electrical stimulation (CMEP) in post-stroke individuals with severe upper limb hemiparesis. MEP status (+/-) of the more affected arm was assessed using TMS and cervicomedullary electrical stimulation in stroke survivors with server upper extremity hemiparesis. While most of the participants were classified as MEP-, all individuals were categorized as CMEP+ in the biceps brachii, extensor carpi radialis, and first dorsal interosseous muscles. Importantly, we report the first testing of CMEPs in a small cohort of individuals with stroke. This technique is feasible in this population and has potential for application in clinical translation settings. Our findings provide a foundation for future studies to replicate and expand upon this approach, enabling the exploration of new hypotheses related to post-stroke rehabilitation and recovery.


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