What other protocols is your doctor using to significantly improve oxygen delivery immediately post stroke? The first hours and days? NOTHING? Then you DON'T have a functioning stroke doctor, do you?
Biomarkers DO NOTHING FOR RECOVERY! Or don't you know that?
Maybe these, why isn't your incompetent doctor already delivering these to you?
cerebral blood flow (29 posts to July 2016)
Cerebral blood flow autoregulation
(1 post to July 2021)
Cerebral Blood Flow Velocity (1 post to Febraury 2020)
cortical oxygenation (1 post to November 2020)
oxygen delivery (20 posts to January 2020)
oxygen uptake (5 posts to August 2013)
Normobaric oxygen (10 posts to January 2020)
Oh, your incompetent doctor doesn't have any and doesn't fucking care about learning better ways to get you recovered! Well, fire them! PREDICTING DAMAGE DOES NOTHING!
The latest here:
Oxygen Extraction Fraction on Baseline MRI Predicts Infarction Growth in Successfully Reperfused Patients
Mona Asghariahmadabad M, Ameera Ismail MD, Pouya Metanat MD, https://orcid.org/0000-0003-2905-4080, Elham Tavakkol MD https://orcid.org/0000-0003-2869-8087 Mersedeh Bahr-Hosseini MD https://orcid.org/0000-0003-3049-4542, Viktor Szeder MD, PhD https://orcid.org/0000-0003-0703-8258, Geoffrey P. Colby MD, PhD https://orcid.org/0000-0002-3376-0933 Show All …
, and Kambiz Nael, MD https://orcid.org/0000-0002-4194-9488 kambiznael@gmail.com Author Info & AffiliationsNew onlineGet AccessAbstract
BACKGROUND:In patients with acute ischemic stroke, infarct growth occurs despite successful reperfusion. Oxygen extraction fraction (OEF) has shown promising results in evaluating ischemic tissue viability and can now be quantified from routinely performed dynamic susceptibility contrast perfusion. We aimed to determine the association of OEF alterations within the ischemic tissue on pretreatment magnetic resonance imaging and infarct growth in patients who underwent successful reperfusion.METHODS:In this retrospective cohort study from the University of California, Los Angeles, between 2015 and 2020, patients were included if they had anterior circulation large vessel occlusion, achieved successful reperfusion (Thrombolysis in Cerebral Infarction ≥2b), had pretreatment dynamic susceptibility contrast perfusion and posttreatment magnetic resonance imaging within 48 hours from reperfusion. Dynamic susceptibility contrast-derived OEF values were quantified from the segmented ischemic core (apparent diffusion coefficient ≤620×10−6 mm2/s) and penumbra tissue (time-to-maximum [Tmax] >6 s) on pretreatment magnetic resonance imaging and normalized to contralateral hemisphere (relative oxygen extraction fraction [OEFr]). Primary outcome was substantial infarct growth ≥10 mL, and secondary outcomes were continuous measures of infarct growth volume and penumbra-to-infarct conversion ratio. The associations between baseline clinical and imaging variables, including OEFr and outcome measures, were tested by multivariate and regression analysis.
RESULTS:
Among 89 patients who met inclusion criteria, 33 (37%) patients had infarct growth ≥10 mL. Patients with infarct growth had significantly (P<0.0001) lower penumbra-OEFr values compared with those without infarct growth. There was significant association between penumbra OEFr and infarct growth (β=−2.9 [95% CI, −5.0 to −0.8]; P=0.007) and similarly for penumbra-to-infarct conversion ratio (β=−10.4 [95% CI, −19.6 to −1.2]; P=0.028).
CONCLUSIONS:
Our results showed penumbra-OEFr is a promising imaging biomarker for predicting infarct growth in acute ischemic stroke following successful reperfusion. Although elevation of penumbra-OEFr is protective, patients with lower penumbra-OEFr values sustained further ischemic injury and infarct growth.
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