Key to Longevity in Isoleucine Reduction

Only in mice, so you may want your doctor to contact researchers to get human testing going.  At least a competent doctor would be doing that.

Don't do this until human testing occurs, isoleucine is needed by your body.

Isoleucine, as one of the branched chain amino acids, is also critical in physiological functions of the whole body, such as growth, immunity, protein metabolism, fatty acid metabolism and glucose transportation. Isoleucine can improve the immune system, including immune organs, cells and reactive substances.

How do you lower isoleucine?

Dairy products and red meat contain the greatest amounts of BCAAs, although they are present in all protein-containing foods. Whey protein and egg protein supplements are other sources of BCAAs. Lowering the intake of these foods can lower the isoleucine plasma levels.

Key to Longevity in Isoleucine Reduction

Summary: Researchers discovered that reducing the amino acid isoleucine in diets can significantly improve health outcomes in mice.

The study reveals that a low-isoleucine diet led to longer lifespans, leaner bodies, and reduced cancer and prostate problems in mice, despite higher calorie consumption.

The findings suggest that isoleucine intake impacts health beyond its caloric value, offering insights into healthy aging and metabolic processes.

This research could pave the way for new dietary recommendations and treatments aimed at improving human health.

Key Facts:

1. A diet low in isoleucine extended the lifespan of mice and improved various health metrics, including body leanness and reduced disease risks.
2. Mice on this diet consumed more calories but maintained leaner bodies and better health due to metabolic adjustments.
3. The study links dietary amino acids to aging processes and healthspan, challenging the traditional view that “a calorie is just a calorie.”

Source: University of Wisconsin-Madison

There’s a popular saying in some circles that “a calorie is a calorie,” but science shows that it may not be true. In fact, it may be possible to eat more of some kinds of calories while also improving your health.

“We like to say a calorie is not just a calorie,” says Dudley Lamming, a professor and metabolism researcher at the University of Wisconsin School of Medicine and Public Health.

“Different components of your diet have value and impact beyond their function as a calorie, and we’ve been digging in on one component that many people may be eating too much of.”

While the results are promising, humans do need isoleucine to live. And winnowing a significant amount of isoleucine out of a diet that hasn’t been preformulated by a mouse chow company is not an easy task. Credit: Neuroscience News