Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 25, 2023

Chronic caffeine consumption curbs rTMS-induced plasticity

I'm not concerned with my one 12 cup pot of coffee daily.  Neuroplasticity is not in any sense scientifically repeatable and I'm more concerned with preventing Parkinsons and dementia. 

Well, the whole reason for drinking the vast amounts of coffee I do is to prevent Parkinsons and dementia.This will not change my mind.

I'm doing a 12 cup pot of coffee a day to lessen my chance of dementia and Parkinsons. Tell me EXACTLY how much coffee to drink for that and I'll change.

How coffee protects against Parkinson’s Aug. 2014  

Coffee May Lower Your Risk of Dementia Feb. 2013 

And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018

How Coffee May Protect Brain Health: A New Study Suggests The Benefits Aren't Just From Caffeine December 2018

Caffeine causes widespread brain entropy (and that's a good thing)

April 2018

This Many Coffees(6) Is Bad For Your Heart Health August 2020(I'm ignoring this one)

Study: The More Coffee You Drink, the Longer You Live July 2018 

The latest here:

Chronic caffeine consumption curbs rTMS-induced plasticity


Megan Vigne1 Jamie Kweon1 Prayushi Sharma1 Benjamin D. Greenberg1,2 Linda L. Carpenter1,2 Joshua C. Brown1,2,3*†
  • 1Neuromodulation Research Facility, TMS Clinic, Butler Hospital, Providence, RI, United States
  • 2Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, United States
  • 3Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, United States

Background: Caffeine is a widely used psychostimulant. In the brain, caffeine acts as a competitive, non-selective adenosine receptor antagonist of A1 and A2A, both known to modulate long-term potentiation (LTP), the cellular basis of learning and memory. Repetitive transcranial magnetic stimulation (rTMS) is theorized to work through LTP induction and can modulate cortical excitability as measured by motor evoked potentials (MEPs). The acute effects of single caffeine doses diminish rTMS-induced corticomotor plasticity. However, plasticity in chronic daily caffeine users has not been examined.

Method: We conducted a post hoc secondary covariate analysis from two previously published plasticity-inducing pharmaco-rTMS studies combining 10 Hz rTMS and D-cycloserine (DCS) in twenty healthy subjects.

Results: In this hypothesis-generating pilot study, we observed enhanced MEP facilitation in non-caffeine users compared to caffeine users and placebo.

Conclusion: These preliminary data highlight a need to directly test the effects of caffeine in prospective well-powered studies, because in theory, they suggest that chronic caffeine use could limit learning or plasticity, including rTMS effectiveness.

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