Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 31, 2026

Hypertension, cardiovascular disease, and nocturia: a systematic review of the pathophysiological mechanisms

 Nocturia - Let me google that for you

Mine is usually only once a night.

Hypertension, cardiovascular disease, and nocturia: a systematic review of the pathophysiological mechanisms

Abstract

Nocturia significantly impairs quality of life, especially in the elderly population, and urinary retention is a main target of treatment for urologists. In addition to nocturia, cardiovascular diseases are common in the elderly population, and a systematic review showed that hypertension and heart failure are often associated with nocturia. One possible pathogenic mechanism underlying the development of hypertension is an increase in blood pressure due to excessive salt intake in people with high-salt sensitivity. From Guyton’s natriuretic curve, we can infer that salt-sensitive hypertensive patients who consume too much salt do not excrete salt during the daytime and are forced to excrete salt at night, resulting in increased urine production and nocturia. In patients with heart failure, the nocturnal supine position leads to an increase in central fluid volume due to an increase in venous return from the periphery, and the secretion of natriuretic peptide is stimulated by the stretching of the atria and ventricles. Thus, natriuresis due to hypertension and hydrodiuresis due to heart failure may cause nocturia, which can effectively be treated by the administration of thiazide diuretics and loop diuretics in the morning, respectively. Because cardiovascular diseases, such as hypertension and heart failure, can cause nocturia and because the treatment methods differ depending on the cause, it is necessary to pay close attention to nocturia in the management of lifestyle-related diseases, such as cardiovascular disease.

The Best Sports for Longevity

 Do you really think your competent? doctor HAS ANY FUCKING IDEA TO GET YOU RECOVERED ENOUGH TO DO THESE? 

Tennis: Nope, two hands needed

Cycling: Nope, not the bicycle version. I don't have enough mental capacity to balance with only one hand.

Swimming: Nope, I can only tread water for a couple seconds with only one hand/arm.

Golf: Nope, not even going to try one-handed golf. 

The Best Sports for Longevity

Mobile Health Applications for Acute Stroke Rehabilitation: An Updated Narrative Review

 So, such lousy research that nothing specific was found that gets survivors recovered!

Mobile Health Applications for Acute Stroke Rehabilitation: An Updated Narrative Review

Abstract

Purpose of Review

This review aims to synthesize current evidence on the use of mobile applications (Apps) for post-stroke rehabilitation, focusing on measurable clinical outcomes related to motor, language, balance, and functional recovery.

Recent Findings

Several mobile Apps have been recently developed for post-stroke rehabilitation. Many studies show significant improvements in validated outcomes such as motor performance, speech intelligibility, and functional independence. Features like gamification, feedback, and virtual or augmented reality enhance engagement and adherence. Overall, app-based interventions appear effective(It's a binary question; effective? Y/N? And your research proved you were total failures in helping survivors!) and feasible both in clinical and home settings.

Summary

From databases search, we found 18 relevant studies from 782 records. We examined study design, functionalities, and reported outcomes. The selected Apps addressed upper-limb rehabilitation, gait and balance training, language recovery, neglect therapy, and physical activity promotion. Significant improvements were consistently observed across validated measures, and immersive virtual or augmented reality systems produced measurable gains in motor performance, user engagement, and quality of life. We found that most interventions were tested in chronic, home-based contexts, and only a few studies were performed in an early acute–subacute inpatient setting, and this field should be better evaluated in future studies.

AIIMS Study Shows Sunlight Therapy Can Improve Stroke Recovery

 When will you do the research that changes it from 'can improve' to WILL IMPROVE DOING THESE EXACT THERAPIES? That is what is needed, not these fucking baby steps our researchers are doing. I'd fire them all for incompetence!

Let's check how long your stroke medical 'professionals' have been INCOMPETENT! 

Over 10 years and your incompetent board of directors hasn't fired them yet?


  • Sun exposure (3 post to May 2013)
  • AIIMS Study Shows Sunlight Therapy Can Improve Stroke Recovery

    Spending just 30 minutes in natural sunlight, along with regular medical treatment, may significantly improve recovery and quality of life among stroke patients, according to a new study conducted by doctors at AIIMS, New Delhi. The findings suggest that sunlight exposure could serve as a simple, affordable addition to post-stroke rehabilitation, especially in resource-limited settings.
    The study was presented during the institute’s fifth Research Day and highlights how a natural and easily accessible intervention can support recovery in patients who often face long, expensive, and demanding rehabilitation journeys.

    Growing Burden of Stroke in India
    Stroke remains one of the leading causes of long-term disability in India. As per Global Burden of Disease estimates, around 1.25 million new stroke cases were reported in the country in 2021, while nearly 9.4 million people continue to live with stroke-related disabilities.
    Recovery is often slow, requiring prolonged therapy, regular hospital visits, and specialised care—services that many patients cannot consistently afford or access. This has created an urgent need for low-cost, home-friendly rehabilitation options.

    How the Study Was Conducted
    The research was carried out between November 2023 and April 2025 and included adult stroke patients aged between 18 and 80 years who had suffered a moderate stroke within the previous month. After screening over 200 patients, researchers selected 40 participants and randomly divided them into two groups.
    One group received standard medical treatment and rehabilitation, while the second group received the same care along with 30 minutes of monitored sunlight exposure on alternate days for 15 days. The intensity of sunlight was carefully measured using a lux meter to ensure safety.

    Better Quality of Life, Sleep and Mood
    Patients who received sunlight therapy showed significant improvement in stroke-related quality of life compared to those on routine care alone. Researchers also observed better sleep patterns and improved mood among patients exposed to sunlight, with no serious side effects reported.
    Doctors believe sunlight may aid recovery by helping regulate sleep cycles, improving vitamin D levels, and reducing inflammation—factors that play a crucial role in healing after a stroke.
    Hope for Home-Based Recovery
    Researchers followed the patients for three months, assessing daily activity levels, mobility, emotional health, sleep quality, and overall well-being. While the study involved a relatively small sample size and was conducted at a single centre, experts say the findings are important.
    Since sunlight is free, safe, and widely available, it could be especially beneficial for patients recovering at home or in rural areas where access to rehabilitation services is limited.

    A Small Step with Big Potential
    With India facing a growing stroke-related disability burden, the study suggests that something as simple as safe daily exposure to sunlight could become a valuable part of post-stroke care if confirmed through larger, multi-centre studies.

    Research shows progress is possible after stroke or spinal injury

     WOW, you think progress is what is needed, rather than full recovery! Your comeuppance is going to be a bitch when you have a stroke and don't recover, because I see NO PROGRESS in solving stroke!

    Research shows progress is possible after stroke or spinal injury

    New research shows that people with spinal cord injuries or strokes can still make progress long after their initial diagnosis through intensive training programmes.

    The findings are based on the INTeRAcT study, conducted by AZ Herentals, KU Leuven, VUB, and To Walk Again, and funded by Belgium’s National Institute for Health and Disability Insurance (RIZIV). This study could pave the way for reimbursement of these therapies.

    The programme focused on personalised and intensive rehabilitation tailored to improve independence and quality of life for people with spinal cord injuries or strokes.

    A spinal cord injury involves damage to the spinal cord, often caused by accidents, leading to paralysis. A stroke can result from either a blood clot (cerebral infarction) or bleeding in the brain. Both conditions have profound, life-altering impacts.

    Patients underwent a 90-hour rehabilitation programme spread over three weeks, with five consecutive six-hour training days each week. Activities included physiotherapy, general therapy, cardiovascular and fitness training, and self-management guidance. Each participant also received one-on-one support and an individualised plan to meet their specific goals.

    The improvements were not only significant immediately after the treatment but also persisted for at least nine months. A follow-up study is planned to examine the long-term benefits of the therapy.

    Marjan Coremans, who coordinated the study, emphasises the transformative impact such programmes can have on patients. “Being able to lift your grandchild—it seems like a small wish but can mean the world for those who can no longer do it,” she said.

    The study involved 100 participants, each closely monitored from the start of the programme and assessed regularly over nine months. The researchers believe the approach could achieve goals once thought impossible.

    We may have been misled about red wine's connection to longevity

     My go to healthy drink is an espresso martini with added chocolate liqueur and maple syrup instead of simple syrup. 

    Highlighted items below are in direct contradiction of these two pieces of research:

    So WHOM TO BELIEVE?  I'm going for the most fun.

     Do you any explanation per this research? Do smarter people have less chance of dementia? I'm pretty sure I qualify.

    Smarter People Tend To Drink More Alcohol. 

    All the research proven benefits follow on my espresso drink. Don't listen to me, I'm not medically trained but love to tweak your medical 'professionals' into defending their ideas.

    This line is great: The findings indicate that even the Espresso Martini cocktail contains the espresso's beneficial compounds - and can contribute to staving off dementia.

    The latest here:

    We may have been misled about red wine's connection to longevity

    Dry January is a time when the “evils” of alcohol hover over us. The warnings about alcohol feel endless: it might increase your risk of dementia, it might cause cancer, it might kill you.

    But if that’s all true, why do so many “Blue Zone” centenarians drink red wine? Why does the American Heart Association say a small amount might reduce your risk of heart attacks? And if it’s that bad, why does the research seem conflicted?

    Must Read: The Trump Administration Wants You To Drink Whole Milk — Here's What Actual Health Experts Want You To Know Of course you should be drinking whole milk; reasons here: 

    We asked experts to break down what we know about red wine — and alcohol in general — and its impact on lifespan. 

    Why We Connect Red Wine With Longevity

    In the popular Netflix documentary “Live To 100,” longevity researcher Dan Buettner showed the habits and environment of centenarians who live in the “Blue Zones.” These are places where people tend to live longer than the rest of the world. In two of those communities, Sardinia, Italy, and Ikaria, Greece, drinking red wine is an important daily ritual.

    “The majority of people in the Mediterranean Blue Zones — who live up to 10 years longer than Americans do — are drinking a glass or two of local red wine daily, usually with a meal, family and friends. We don’t know if they are living longer because of the wine, the fellowship or the combination of both,” Buettner said in an email to HuffPost.

    There may not be enough polyphenols in a glass of wine to make a difference, and cardiovascular impact has also been observed when people drink other types of alcohol.

     While this population tends to drink wine as they eat and socialize, they follow other healthy habits, too. Their diet is high in fruits and vegetables, they are close with family and friends, and they get regular exercise. It’s possible that these other practices outweigh the moderate indulgences. “It remains unknown whether drinking can be part of a healthy lifestyle,” saidDr. Mariann Piano, professor emeritus of nursing at Vanderbilt University. “Clearly, drinking too much — and that includes more than two drinks a day — is associated with many adverse cardiovascular effects. … I think the controversy is more around the low to moderate levels.”

    Must Read: The Audacity Of Going To A Mexican Restaurant When You're An ICE Officer

    Here’s The Controversy

    Research clearly shows that excessive alcohol consumption and binge drinking can lead to medical issues, but the impact of lower quantities is more complicated.

    Studies have shown that light drinkers may have lower mortality than both abstainers and heavy drinkers. Some researchers contest the finding, but Dr. Eric Rimm, a professor of epidemiology and nutrition at the Harvard T.H. Chan School of Public Health, attributes it to a reduced risk of cardiovascular disease.“It does look like people who drink half a drink to one drink a day, which means three to seven drinks a week, live the longest,” Rimm said. “Most of that is explained by the fact that they have lower rates of heart attacks — and heart attacks cause death.”

    In fact, heart disease is the No. 1 cause of death in the developed world. 

    Must Read: Your Choice Of Afternoon Snack Could Increase Your Risk Of Dementia

    In June, the American Heart Association released a review showing that low levels of alcohol showed no risk, or potentially lowered risk, of cardiovascular conditions. In small amounts, it can raise good cholesterol, have a blood-thinning effect and lower blood pressure. This was not specific to red wine, though.

    You may have heard that the polyphenols, or antioxidants, in red wine are what cause this, but this is unproven. There may not be enough polyphenols in a glass of wine to make a difference, and the cardiovascular impact has also been observed when people drink other types of alcohol.Your heart isn’t the only area of focus when it comes to your body’s reaction to alcohol. Small quantities may also reduce the risk of developing Type 2 diabetes. 

    “Moderate alcohol, 5 to 10 ounces a day, has been shown to potentially reduce the risk of developing Type 2 diabetes. Interestingly, some of the studies showed patients even losing a few pounds over time. … And even in our diabetic patients, we’re seeing improvements in blood sugars with moderate alcohol use, in particular with red wine,” said Dr. Steven Zygmont, diabetes and metabolism endocrinologist with Crouse Health. 

    Must Read: Shoppers Swear Employees At This Grocery Store Are Trained To Flirt With You

    It’s possible that the polyphenols cause red wine to have a slightly better effect than other drinks, or it may be a result of the way that people typically consume red wine. 

    Health practitioners have major concerns about communicating these findings, which can easily be misunderstood. 

    “It’s a really tricky public health message because of all of the dangers of alcohol,” Rimm said. “It’s unlike other things in public health, because if you tell people, ‘you should have more fruits and vegetables,’ they’re not likely to binge on fruits and vegetables on Friday and Saturday. But alcohol has the problem that the pattern is probably equally as important as the amount,” Rimm said.


    Given the addictive nature of alcohol, one glass of wine can easily become two or more. It’s a fine line: Drinking a little has a low risk, but increasing the amount can dramatically raise your risk.

    Plus, regardless of the other health implications, alcohol — including wine — is a known carcinogen. So, while heart disease remains the leading cause of death, cancer follows closely in second place. When it comes to cancer risk, there’s no safe amount of alcohol. 

    Must Read: You May Want To Think Twice Before You Eat Bagged Lettuce

    “Risks related to cancer should not be ignored, and considered on an individual basis,” Piano said. “Some advice we give to people is, ’If you have a really strong family history of cancer, then you may want to have less or no alcohol. Everybody can choose to drink nothing; however, there are many lifestyle behaviors we can engage in to reduce our risk of chronic disease.”

    How To Make Informed Choices

    So, what does wine actually look like in the longevity picture? 

    Keeping the science in mind while looking at the Blue Zones of Sardinia and Ikaria, we see a tradition of drinking wine with meals as part of an overall healthy lifestyle. Wine tends to be shared in social settings over food, which can limit amounts and slow the pace, easing the load as the body works to metabolize toxins. 

    “I think [red wine] is more linked to other positive eating and physical activity behaviors,” Piano said, pointing to a study that found a small protective association with preferences for wine and consuming alcohol with meals. This could be due to slower alcohol absorption, and it might reflect the lifestyle choices of people who prefer red wine as their drink of choice. 

    “There are just too many unknowns at this time, except that drinking too much (and that includes more than two drinks a day) is associated with a lot of adverse cardiovascular effects,” Piano said.

    Even if there is a protective effect associated with wine, it has serious limits. While light drinkers may have reduced cardiovascular risk, heavier drinkers have a significantly increased risk of heart attack, high blood pressure or stroke. Light drinkers tend to have lower rates of cognitive decline, but heavier drinkers are more likely to develop dementia. Light drinkers are less likely to develop diabetes, but excess drinking is a significant risk factor for Type 2 diabetes.

    In 2023, the Canadian Centre on Substance Use and Addiction tried to organize this risk into charts to help people understand the continuum, which you can see here.

    “Alcohol use cannot be addressed with a blanket statement, which I know is what the public wants,” Piano said. “Nonetheless, from a public health perspective, it is important to highlight the risk of cancer and chronic diseases, with higher consumption linked to greater harm. Be more intentional and mindful about what you’re drinking. … People need to understand what their risk is, and then it’s going to be up to them.”

    So, if you are going to drink, is red wine the best choice? It’s possible that wine may have a slight edge over other types of alcohol due to its composition, but its main advantage probably lies in the traditions that surround it. Although there’s no definitive answer, one thing is clear: If you’re going to indulge in red wine, keep portions small, because healthy food and good company seem to be far more important for longevity than wine alone. 


    Hidden fat in your body type may put you at greater brain risk, finds study

     Have your competent? doctor identify EXACTLY where your fat is AND PROVIDE PROTOCOLS TO REDUCE THAT FAT!

    Hidden fat in your body type may put you at greater brain risk, finds study

    Electromagnetic therapy that stimulates the brain reduces overall disability in stroke survivors

    Have you rolled out the EXACT PROTOCOL to all 10 million yearly survivors? NO?  So, you're COMPLETELY FUCKING INCOMPETENT?

    And our fucking failures of stroke associations can't be depended on to do it, in my opinion, they KNOW NOTHING/DO NOTHING!  Prove me wrong by pointing to EXACT RECOVERY PROTOCOLS THEY HAVE PRODUCED! Not guidelines, guidelines are practically worthless!


    Electromagnetic therapy that stimulates the brain reduces overall disability in stroke survivors

    A type of therapy that stimulates specific brain pathways with electromagnetic pulses combined with physical therapy significantly reduced overall disability in stroke survivors compared to survivors who received sham (inactive) electromagnetic stimulation combined with physical therapy, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2026. The meeting is in New Orleans, Feb. 4-6, 2026, and is a world premier global event dedicated to advancing stroke and brain health science.

    Although advances in stroke treatments have saved lives, many survivors still face disabilities that prevent them from returning to their normal daily activities. According to researchers, one promising treatment, called electromagnetic network-targeted field (ENTF) therapy, stimulates the interconnected networks related to motor movement, cognitive functions and other brain activities.

    "These neural networks show electrical disorganization after a stroke. Stimulating these networks with electromagnetic pulse patterns derived from studies in people who have not had a stroke can model and facilitate the reestablishment of normal network organization," said lead study author Jeffrey L. Saver, M.D., FAHA, who is a distinguished professor, SA vice chair for Clinical Research, and holder of the Carol and James Collins (endowed) chair in the department of Neurology at the David Geffen School of Medicine at UCLA. "This therapy has shown beneficial effects upon organized brain electrical activity and, most importantly, was associated with improved functional recovery for patients after stroke."

    Researchers examined the combined data from two double-blind, randomized, controlled studies (meaning both participants and researchers did not know who received actual vs. placebo or sham treatment) to characterize the potential effects of ENTF therapy on reducing disability after ischemic stroke. In total, 124 stroke survivors were included in the analysis: 65 were treated with ENTF therapy, and 59 received an inactive or sham treatment. Participants were enrolled in the study on average 14 days after their stroke occurred and were moderately to severely disabled; the average modified Rankin Scale (mRS) score was 3.9 at enrollment. All participants received 40 to 45 sessions of ENTF therapy or sham treatment over 8 to 12 weeks, and both groups received physical therapy during the stimulation sessions. In both trials, participants began ENTF therapy in the hospital and continued with at-home treatments using portable kits. Participants were assessed for overall disability and their motor and cognitive abilities after three months of treatment.

    The analysis found:

    • The percentage of participants who achieved freedom from disability was 22% higher in the ENTF group compared to the group that received the sham treatment (33.8% versus 11.9%, respectively).
    • Measurable improvements were also seen in ENTF participants' disability levels across the full range of disability outcomes, with both less moderately to severe disability (mRS of 3-5) and less moderate disability (mRS of 2).
    • No serious adverse effects were reported among participants who received ENTF therapy.

    It's clear that we need more effective rehabilitation therapies to fully improve patient outcomes. This promising potential therapy is unique in that it would be able to be conducted at home by the stroke survivor using a portable kit."

    Jeffrey L. Saver, lead study author 

    American Stroke Association volunteer expert Joseph P. Broderick, M.D., FAHA, said, "This study examines two small trials of electromagnetic network-targeted field (ENTF) therapy for stroke patients. The results are preliminary, highlighting the need for larger trials with balanced participant groups to assess the therapy's effectiveness. ENTF showed no safety issues, and there's a strong demand for new recovery methods post-stroke." Broderick is a professor at the University of Cincinnati's Gardner Neuroscience Institute, part of the University of Cincinnati College of Medicine in Ohio and was not involved in this study.

    The main limitation of the study is that it is an analysis of data from two small pilot studies. A single, larger trial is needed to confirm these results.

    In the United States, stroke is the fourth leading cause of death and a leading cause of long-term disability, according to the American Heart Association's Heart Disease and Stroke Statistics 2026 Update. Depending on the part of the brain affected, stroke may impair arm and/or leg movement and activities of daily life among survivors. Motor impairment (arm and/or leg weakness) is the most common complication after stroke.

    Study details, background and design:

    • The study included 124 adults who had an ischemic stroke, and a baseline modified Rankin Score (mRS) of 3.9, indicating moderate to severe disability. Participants' average age was 58 years and 31% were women.
    • Data were derived from two double-blind, randomized, sham-controlled trials (the BQ3 and EMAGINE trials, conducted between 2021 and 2025). Researchers combined the individual patient data into a single meta-analysis to characterize the potential effects of ENTF therapy on overall disability after stroke.
    • Participants in these two trials were randomized to receive either ENTF therapy or a sham treatment between four and 21 days after stroke. Sixty-five (65) participants received 40-45 sessions of ENTF therapy, and 59 received the sham intervention. Both groups also received physical therapy as part of their stroke rehab care.
    • The primary outcome of the analysis was for participants to be disability-free, as measured by an mRS score of 0-1, at 8-12 weeks.

    Early Recognition and Intervention for Poststroke Spasticity: A Scientific Statement From the American Heart Association

     WOW! And you think this does anything at all to get spasticity cured? You're fucking delusional!

    I will against my better nature hope all of you discover comeuppance when you have spasticity and DON'T RECOVER!

    Early Recognition and Intervention for Poststroke Spasticity: A Scientific Statement From the American Heart Association

    Sujani Bandela, MD, Vice Chair, 
    Laura McPherson, DPT, PhD, 
    Richard L. Harvey, MD, FAHA, 
    Oluwole Awosika, MD, 
    Dipika Aggarwal, MD, 
    Charles Y. Liu, MD, 
    Preeti Raghavan, MD, FAHA, and 
    Mark P. Goldberg, MD, FAHA, Chair on behalf of the American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Basic Cardiovascular Sciences; Council on Lifestyle and Cardiometabolic HealthAuthor Info & Affiliations
    Stroke
    New online
    https://doi.org/10.1161/STR.0000000000000515

    Abstract

    Spasticity and related motor disorders are common and often disabling complications after stroke, affecting an estimated 30% to 80% of survivors. Spasticity can impair functional mobility, reduce independence, and increase caregiver burden. Secondary complications, including pain, restricted range of motion, skin breakdown, and joint contractures, further degrade quality of life, limit rehabilitation outcomes, and increase health care costs. Despite the availability of options to manage spasticity and mitigate its effects, timely diagnosis and intervention remain key challenges. Many patients receive treatment only after spasticity has become well established, and others receive no treatment at all due to persistent disparities in recognition, access, and delivery of treatment for spasticity, contributing to long-term disability and increased costs of care(NOT RECOVERY!). This scientific statement reviews the rationale, established and emerging evidence, and strategic approaches for improving early recognition and intervention for poststroke spasticity. Early intervention is defined as treatment initiated within the first 3 months after stroke onset, potentially before development of secondary impairment from poorly controlled spasticity. Recognizing spasticity as a multidomain clinical syndrome—including involuntary muscle overactivity, impaired voluntary motor control, and passive tissue remodeling—offers important opportunities to improve timely diagnosis and treatment. Progress will also depend on a deeper understanding of the time course and pathophysiology of spasticity through both animal and human models. This scientific statement also outlines strategies to close gaps in recognition and care(NOT RECOVERY!), including expanding and training the specialist workforce; developing innovative, scalable approaches for early detection and management; and strengthening care(NOT RECOVERY!) pathways and access to meet the substantial unmet needs of patients with poststroke spasticity.
    Spasticity is a common and often debilitating consequence of stroke, affecting an estimated 25% to 80% of survivors.1–6 This translates to ≈1.8 to 5.6 million stroke survivors in the United States alone. Globally, spasticity is estimated to affect >100 million individuals after stroke.6 Poststroke spasticity substantially affects functional recovery, quality of life, and long-term independence.5
    The 2016 American Heart Association/American Stroke Association guidelines for adult stroke rehabilitation and recovery note that the cost of care(NOT RECOVERY!) is 4 times higher when spasticity is present and suggests approaches for recognition and treatment of spasticity.7 Nevertheless, spasticity remains underrecognized and undertreated. For many patients, this results in prolonged disability and the emergence of preventable secondary complications, which increases overall health care(NOT RECOVERY!) costs.2
    The optimal timing for initiation of spasticity-related interventions is a crucial yet unresolved aspect of poststroke care(NOT RECOVERY!). For the purposes of this scientific statement, early intervention refers to treatment initiated within the first 3 months after stroke onset. The 3-month time window is consistent with previous studies of early spasticity intervention,8,9 and is not meant to exclude treatment approaches that might be initiated earlier in the poststroke course.
    This scientific statement provides an overview of the current landscape of the diagnosis and management of poststroke spasticity, reviews the rationale for and available evidence supporting early treatment, and outlines future opportunities to reduce spasticity through early rehabilitative approaches. We identify key strategies to improve timely spasticity care(NOT RECOVERY!) by increasing awareness among patients and health care professionals to facilitate early recognition of risks and symptoms, and developing cost-effective, scalable models to improve access to care(NOT RECOVERY!), especially for high-risk individuals. Addressing these challenges will be essential for improving outcomes for the millions of people with poststroke spasticity.
    More at link.

    Is Lithium Orotate the Key to Preventing Alzheimer’s Disease?

     Dies your doctor even know of your risk of dementia post-stroke? And has EXACT PREVENTION PROTOCOLS? NO? So, you DON'T have a functioning stroke doctor, do you?

    Do you prefer your doctor, hospital and board of director's incompetence NOT KNOWING? OR NOT DOING? Your choice; let them be incompetent or demand action!

    You need this prevention!

    1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

    2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

    3. A 20% chance in this research.   July 2013.

    4. Dementia Risk Doubled in Patients Following Stroke September 2018  

    The latest here:

    Is Lithium Orotate the Key to Preventing Alzheimer’s Disease?

    This transcript has been edited for clarity. 

    Hello. I’m Dr JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women’s Hospital. I’d like to talk with you about a recent exciting and potentially breakthrough study, published in Nature, that suggests a novel approach to preventing Alzheimer’s disease. 

    The research was led by Dr Bruce Yankner and colleagues at Harvard Medical School. They conducted a series of studies that pointed to a promising role of lithium orotate in reducing Alzheimer’s risk. I’ll briefly summarize the lines of evidence but want to emphasize that these findings need to be confirmed by a rigorous randomized trial before lithium orotate should be considered ready for primetime. Our research group, in collaboration with Dr Yankner, will soon be launching such a large-scale human trial and appreciate the philanthropic support that has made this possible. 

    The lines of evidence supporting a role of lithium orotate in dementia prevention include the following, as reported in the Nature article. The researchers were able to do this research because they had access to post-mortem brain tissue across several groups: people with no cognitive impairment, mild cognitive impairment, and Alzheimer’s disease. They evaluated 27 different metals, and lithium was the only metal that showed significantly lower levels in the postmortem brains of people with cognitive impairment, and especially those with Alzheimer’s disease, compared with cognitively healthy individuals. They also found that the amyloid beta plaques bind and trap lithium, which further reduces lithium availability in the brain and also suggests that lithium loss may be an early and specific biochemical change in the brains of people with Alzheimer’s disease. 

    The researchers also conducted studies in mice to assess causation. They fed mice a lithium-restricted diet and found that they developed accelerated amyloid beta and tau pathology, neuroinflammation-reduced myelin, synapse loss, and memory and cognitive deficits. The changes were similar to the hallmark features of human Alzheimer’s disease. They then tested 16 different lithium salts and identified lithium orotate as having several unique and promising features, including low binding to amyloid beta (avoiding the trap that limited other lithium salts), the ability to restore lithium availability in the brain, and cognitive and pathological improvement in the mouse brain. 

    In both Alzheimer’s disease mouse models and aging wild-type mice, lithium orotate prevented and reversed amyloid plaque and tau accumulation, other pathological brain changes, and cognitive decline and memory loss.

    Prior to this research, only limited data were available on this topic. There were some epidemiologic observational studies, such as a few linking higher lithium levels in drinking water with lower dementia incidence, but prior research on lithium use and dementia risk has been inconclusive. Additionally, high doses of traditional lithium salts, such as lithium carbonate used for bipolar disorder, can be toxic and poorly tolerated, especially in older adults, so we still need confirmatory randomized trials of lithium orotate and dementia prevention in humans. 

    The formulation appears to matter. Lithium orotate is an amyloid-evading salt, and it has not been tested in well-controlled human trials. Its safety, efficacy, and long-term tolerability remain unknown. Routine clinical use of lithium orotate isn’t yet ready for prime time until such trials are completed, but these are exciting findings that may hold the key to a novel approach to preventing Alzheimer’s disease.