Deans' stroke musings: Prognostic significance of the C-reactive protein–albumin–lymphocyte index and the pan-immune-inflammation value in ischemic and hemorrhagic stroke: a comparative analysis of subtypes

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, January 23, 2026

Prognostic significance of the C-reactive protein–albumin–lymphocyte index and the pan-immune-inflammation value in ischemic and hemorrhagic stroke: a comparative analysis of subtypes

Prognostication and assessments do nothing for stroke survivor recovery. And I see NO protocol for reducing the risk of stroke based on these measurements; SO COMPLETELY FUCKING USELESS!

Prognostic significance of the C-reactive protein–albumin–lymphocyte index and the pan-immune-inflammation value in ischemic and hemorrhagic stroke: a comparative analysis of subtypes

Canan Şahin^*^†

Yahya Şahin^†

Department of Emergency Medicine, Ahi Evran University Faculty of Medicine, Kırşehir, Türkiye

Background: Cerebrovascular events are major causes of global mortality and disability. Inflammation, immune response, and nutritional status play crucial roles in stroke pathophysiology. The C-reactive protein–albumin–lymphocyte (CALLY) index and the pan-immune-inflammation value (PIV) are novel composite biomarkers reflecting these mechanisms. This study compared their prognostic performance between ischemic and hemorrhagic stroke.

Methods: This retrospective, single-center cohort included 357 patients diagnosed with ischemic or hemorrhagic stroke between January 2020 and December 2024. Demographic, clinical, and laboratory data were retrieved from electronic records. Indices including CALLY, PIV, HALP, SII, and MII were calculated from blood samples obtained within 24 h of admission. Group comparisons, multivariate logistic regression, and receiver operating characteristic (ROC) analyses identified independent predictors and diagnostic performance.

Results: Among 357 patients (mean age 67 ± 14 years; 56.6% ischemic, 43.4% hemorrhagic), the CALLY index was significantly higher in hemorrhagic cases (p < 0.001). Multivariate analysis identified CALLY (odds ratio = 1.255), PIV (odds ratio = 1.001), and HALP (odds ratio = 1.258) as independent predictors (all p < 0.001). CALLY showed the highest discriminative ability (area under the ROC curve = 0.756). In hemorrhagic stroke, lower CALLY values were associated with in-hospital mortality (AUC = 0.646, p = 0.002).

Conclusion: The CALLY index demonstrated superior prognostic value compared with other inflammatory markers and may serve as a simple, low-cost tool for early stroke risk assessment. Prospective, multicenter studies are warranted to validate these findings and to establish standardized cutoff values.