Deans' stroke musings: Ferroptosis and Alzheimer's Disease: A New Insight into Neurodegeneration

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, January 26, 2026

Ferroptosis and Alzheimer's Disease: A New Insight into Neurodegeneration

Your doctor, if competent at all, should have already known about ferroptosis from this research from September 2017. And should have initiated stroke treatment interventions from it. But I bet incompetence prevailed! No excuses are allowed, call that president and have these incompetent doctors fired!

Dementia research leads to potential new stroke treatment

The latest here:

Ferroptosis and Alzheimer's Disease: A New Insight into Neurodegeneration

Youfang Quan¹

Hongwei Liu²

Minheng Zhang³ Meng Li

Meng Li⁴

Bo He¹

Shengyang Zhou⁵

¹Chengdu University of Traditional Chinese Medicine, Chengdu, China
²Capital Medical University, Beijing, China
³The First People's Hospital of Jinzhong, Jinzhong, China
⁴Shanxi Medical University, Taiyuan, China
⁵Southeast University, Nanjing, China

The final, formatted version of the article will be published soon.

Alzheimer's disease (AD), a chronic and progressive neurodegenerative disorder, poses a significant threat to the health of the aging population. The pathological hallmarks of AD include the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) within the brain. While substantial neuronal loss has been consistently observed in AD, the precise mechanisms underlying neuronal elimination remain incompletely understood. As a distinct form of regulated cell death, the contribution of ferroptosis to AD pathogenesis and progression warrants further investigation(If your doctors and hospital can't get this further research done, then it's time to keel haul them!). This review critically examines the amyloid cascade hypothesis within the context of AD, with particular emphasis on the molecular signatures of ferroptosis and their contributions to canonical AD pathogenesis and cognitive decline. We aim to provide an updated perspective on AD etiopathogenesis. Furthermore, we synthesize current therapeutic strategies targeting ferroptosis inhibition in AD, highlighting recent advances that hold significant implications for guiding present and future translational efforts.