Deans' stroke musings: Gamma frequency entrainment attenuates amyloid load and modifies microglia

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 17, 2026

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Ask your competent? doctor how to EXACTLY do this even before human testing occurs! No ability to extrapolate; PURE INCOMPETENCE!

Or maybe you want to do the 60 Hertz one, just ask your competent? doctor to clarify.

60 Hertz flickering light (4 posts to July 2021)

40Hz sensory stimulation (3 posts to March 2021)

Already bought a 40H flickering light for dementia prevention, might need to get a 60H one. Don't do that unless you get a doctor's prescription.

Gamma frequency entrainment attenuates amyloid load and modifies microglia

Affiliations

PMID: 27929004
PMCID: PMC5656389
DOI: 10.1038/nature20587

Erratum in

Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH.Nature. 2018 Oct;562(7725):E1. doi: 10.1038/s41586-018-0351-4.PMID: 30046102
Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia.
Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH.Nature. 2024 Dec;636(8042):E2. doi: 10.1038/s41586-024-08343-7.PMID: 39592835 No abstract available.

Abstract

Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)1-40 and Aβ 1-42 isoforms. Gene expression profiling revealed induction of genes associated with morphological transformation of microglia, and histological analysis confirmed increased microglia co-localization with Aβ. Subsequently, we designed a non-invasive 40 Hz light-flickering regime that reduced Aβ1-40 and Aβ1-42 levels in the visual cortex of pre-depositing mice and mitigated plaque load in aged, depositing mice. Our findings uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology.

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