http://onlinelibrary.wiley.com/doi/10.1002/hipo.22520/abstract
DOI: 10.1002/hipo.22520
© 2015 Wiley Periodicals, Inc.
Issue
Additional Information(Show All)
- Abstract
- Supporting Information
- Cited By
Keywords:
- hippocampus;
- plasticity;
- stem cells;
- memory;
- environmental enrichment;
- exercise
Abstract
We
here show that living in a stimulus-rich environment (ENR) improves
water maze learning with respect to specific key indicators that in
previous loss-of-function experiments have been shown to rely on adult
hippocampal neurogenesis. Analyzing the strategies employed by mice to
locate the hidden platform in the water maze revealed that ENR
facilitated task acquisition by increasing the probability to use
effective search strategies. ENR also enhanced the animals' behavioral
flexibility, when the escape platform was moved to a new location.
Treatment with temozolomide, which is known to reduce adult
neurogenesis, abolished the effects of ENR on both acquisition and
flexibility, while leaving other aspects of water maze learning
untouched. These characteristic effects and interdependencies were not
seen in parallel experiments with voluntary wheel running (RUN), a
second pro-neurogenic behavioral stimulus.
Since
the histological assessment of adult neurogenesis is by necessity an
end-point measure, the levels of neurogenesis over the course of the
experiment can only be inferred and the present study focused on
behavioral parameters as analytical endpoints. Although the correlation
of physical activity with precursor cell proliferation and of learning
and the survival of new neurons is well established, how the specific
functional effects described here relate to dynamic changes in the stem
cell niche remains to be addressed. Nevertheless, our findings support
the hypothesis that adult neurogenesis is a critical mechanism
underlying the beneficial effects of leading an active live, rich in
experiences. This article is protected by copyright. All rights
reserved.
No comments:
Post a Comment