Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 33,991 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Green tea intake leads to less incidence of cognitive declines in elderly people.
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intake improves cognition abilities in patients with psychiatric disorders.
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Theanine promotes cell growth and neuronal differentiation in neural progenitor.
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Theanine up-regulates Slc38a1 transcript expression in neural progenitor.
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Theanine activates phosphorylation of mTOR in neural progenitor.
Abstract
The
green tea amino acid theanine is abundant in green tea rather than
black and oolong teas, which are all made of the identical tea plant
“Chanoki” (Camellia sinensis). Theanine has a molecular structure close
to glutamine (GLN) compared to glutamic acid (Glu), in terms of the
absence of a free carboxylic acid moiety from the gamma carbon position.
Theanine efficiently inhibits [3H]GLN uptake without affecting [3H]Glu
uptake in rat brain synaptosomes. In contrast to GLN, however, theanine
markedly stimulates the abilities to replicate and to commit to a
neuronal lineage following prolonged exposure in cultured neural
progenitor cells (NPCs) prepared from embryonic and adult rodent brains.
Upregulation of transcript expression is found for one of the GLN
transporter isoforms, Slc38a1, besides the promotion of both
proliferation and neuronal commitment along with acceleration of the
phosphorylation of mechanistic target of rapamycin (mTOR) and relevant
downstream proteins, in murine NPCs cultured with theanine. Stable
overexpression of Slc38a1 similarly facilitates both cellular
replication and neuronal commitment in pluripotent embryonic carcinoma
P19 cells. In P19 cells with stable overexpression of Slc38a1,
marked phosphorylation is seen for mTOR and downstream proteins in a
manner insensitive to further additional phosphorylation by theanine.
Taken together, theanine would exhibit a novel pharmacological property
to up-regulate Slc38a1 expression for activation of the
intracellular mTOR signaling pathway required for neurogenesis after
sustained exposure in undifferentiated NPCs in the brain. In this
review, a novel neurogenic property of the green tea amino acid theanine
is summarized for embryonic and adult neurogenesis with a focus on the
endogenous amino acid GLN on the basis of our accumulating evidence to
date.
Graphical abstract
Long-term
exposure to theanine could lead to upregulation of Slc38a1 expression
for the facilitated incorporation of extracellular GLN (①) in NSCs,
followed by increased intracellular levels of GLN and subsequent
stimulation of the exchange transport mediated by the antiporter
Slc7a5/8 of intracellular GLN with extracellular EAA (②). Increased
intracellular EAA levels would thus result in activation of the mTOR1
signaling pathway (③,④) required for the upregulation of different bHLH
transcription factors (⑤) essential for modulation of neurogenesis (⑥)
in NSCs.
The
present study investigated the neuroprotective effect of
gamma-glutamylethylamide (theanine), a component Japanese green tea
(Camellia sinensis), on memory impairment induced by twice-repeated
cerebral ischemia in rats. Theanine was injected i.p. immediately after
the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented
the impairment of spatial memory in rats subjected to repeated cerebral
ischemia, 7 days after the second reperfusion. Moreover, theanine (1
mg/kg) significantly inhibited the decrease in the number of surviving
cells in the hippocampal CA1 field in the same rats. These results
suggest that theanine prevents memory impairment induced by repeated
cerebral ischemia, in part by protecting against neuronal cell death,
and that it might be useful for preventing cerebrovascular disease.
Except that when you buy them you have no fucking clue what is in them due to our stupid federal legislators passing the
Dietary Supplement Health and
Education Act of 1994 (DSHEA): (DSHEA) defined dietary supplements as a
category of food, which put
them under different regulations than drugs. They are considered safe
until proven otherwise. Caveat Emptor. This recalls the patent medicines
in the 18th and 19th centuries. It took the Pure Food and Drug Act of
1906 to reign those in. https://www.yahoo.com/news/4-supplements-brain-smart-drugs-163003666.html
What a fun-looking word: nootropics.
It refers to any type of compound or food that has the ability to
improve your mental abilities, including your memory, ability to focus,
motivation, or even mood. While the general category most definitely
includes smart drugs, neuro-enhancing supplements fit the bill as well.
Daily, neuroscientists are acquiring a more nuanced understanding of the
brain, the result being many new pharmaceutical drugs which target
exact regions of the brain are in the works. The very same knowledge,
though, might reveal how particular supplements might do an equally good
job of improving brain function over the long haul.
Why go for prescription-strength when you can get the same by shopping the vitamin aisle?
In
that spirit, here’s a list of dietary supplements you could investigate
for their potential use as a nootropic. Remember: Do your research and
ask a doctor’s advice before popping any pill, natural or not. More
importantly, not all dietary supplements are created equal, with some
brands including additives you may not want (or are allergic to), so
it’s important to vet any unfamiliar manufacturers.
Creatine is
an old favorite among gym rats, who use it to enhance their sports
performance, but over the past decade or so, the supplement’s
neuro-enhancing abilities have been demonstrated as well. In one
placebo-controlled study,
researchers tested the hypothesis that 5 grams a day for a six-week
period would enhance intelligence test scores while also improving
memory. They enlisted the help of 45 young adult, vegetarian subjects
and found the supplement had a significant positive effect on both
working memory and intelligence, particularly with regard to tasks that
require speed of processing. Though they tested vegetarians, the
researchers would “expect to see a beneficial effect of creatine
supplementation on brain performance in most omnivores apart from those
who consume very high amounts of meat.”
Theanine (or
more commonly L-theanine) is found in green tea and mushrooms and also
sold as a dietary supplement in the United States. In fact, the Food and
Drug Administration has granted it GRAS status (generally recognized as
safe). According to various scientific studies,
theanine has been found to affect the levels of some neurotransmitters,
to prevent beta-amyloid-induced brain dysfunction, and to protect
against stroke. L-theanine is even said to improve sleep quality in boys
with attention deficit hyperactivity disorder. In terms of potential
nootropic uses, several small studies indicate a combination of
L-theanine and caffeine can improve cognitive performance, particular in
the areas of focus and alertness. Apparently, though, the effects may
not be long-lasting.
Passionflower is derived from the above ground parts of the plant. Primarily, people take it for its anti-anxiety effects,
which have been proven in smaller scientific studies though not yet
confirmed in large scale studies. Some other people use it to treat
insomnia as well as neuralgia and withdrawal symptoms while coming off
opiates or benzodiazepines. In patients undergoing surgery as well as
those about to be treated by a dentist, passionflower has been
effectively used to reduce apprehension.
DHA,
an omega-3 fatty acid found in fish and seaweed, can improve your
memory while protecting against certain psychiatric disorders. Various
surveys of people with major depression indicate they have depleted
levels of omega-3 fatty acids and one large study found depressive
symptoms were significantly higher among infrequent fish consumers.
However, no study has ever proven omega-3 fatty acid supplementation
effective in relieving major, moderate, or even mild depression. That
said, some data suggest it is a safe preventive measure and may reduce
the risk of progression of certain psychiatric disorders. While one
review of scientific studies found that DHA supplements significantly
improves cognitive development in infants — though does not improve
cognitive performance in children, adults, or the elderly — another review shows
it can protect against mild cognitive impairment, dementia, and the
risk and progression of Alzheimer's disease in the elderly.
Theanine, γ-glutamylethylamide, is one of the major amino acid components in green tea. In this study, cognitive function and the related mechanism were examined in theanine-administered young rats. Newborn rats were fed theanine through dams, which were fed water containing 0.3% theanine, and then fed water containing 0.3% theanine after weaning. Theanine level in the brain was under the detectable limit 6 weeks after the start of theanine administration. Theanine administration did not influence locomotor activity in the open-field test. However, rearing behavior was significantly increased in theanine-administered rats, suggesting that exploratory activity is increased by theanine intake. Furthermore, object recognition memory was enhanced in theanine-administered rats. The increase in exploratory activity in the open-field test seems to be associated with the enhanced object recognition memory after theanine administration. On the other hand, long-term potentiation (LTP) induction at the perforant path-granule cell synapse was not changed by theanine administration. To check hippocampal neurogenesis, BrdU was injected into rats 3 weeks after the start of theanine administration, and brain-derived neurotropic factor (BDNF) level was significantly increased at this time. Theanine intake significantly increased the number of BrdU-, Ki67-, and DCX-labeled cells in the granule cell layer 6 weeks after the start of theanine administration. This study indicates that 0.3% theanine administration facilitates neurogenesis in the developing hippocampus followed by enhanced recognition memory. Theanine intake may be of benefit to the postnatal development of hippocampal function.
