Intracellular and intercellular crosstalk between exosomes and autophagy

Your competent? doctor needs to understand exactly the good work exosomes do in conjunction with the cleanup work of autophagy.

And here is the needed research on autophagy and exosomes: Has your incompetent doctor implemented any of it?

autophagy (19 posts to October 2011)

exosomes (57 posts to March 2011)

 Autophagy is a cellular process where a cell breaks down and recycles its own components, like damaged organelles and proteins, within the lysosome. It's essentially a cellular "housekeeping" function, clearing out cellular debris and recycling materials for energy. This process is also known as "self-eating"

Exosomes are what does the good work when stem cells are introduced.

Intracellular and intercellular crosstalk between exosomes and autophagy

• Qilong Li^1,2, 
• Sisi Chen^1,2, 
• Yunju Yin³, 
• Mengmeng Han¹, 
• Hanjing Shi⁴, 
• Yu Gong⁵, 
• Xinyue Duan^1,2, 
• Yonglang Wang^1,2, 
• Qiuping Guo¹, 
• Yehui Duan¹, 
• Yulong Yin^1,2, 
• Fengna Li^1,2, , 

• 1.

  Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China

• 2.

  College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

• 3.

  Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China

• 4.

  Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410081, China

• 5.

  College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

More Information

The Innovation Life  https://doi.org/10.59717/j.xinn-life.2025.100132  |  Cite this article

• GRAPHICAL ABSTRACT

  

• PUBLIC SUMMARY

  1. The homeostatic role between exosomes and autophagy depends on the intracellular and intercellular crosstalk.

     Their intracellular connections intersect through shared molecular machinery or organelle.

     Exosomal miRNAs and proteins activate or inhibit autophagy-related signals to mediate intercellular crosstalk.

• ABSTRACT

  The intracellular and intercellular information exchange is the key to regulate the body function. Current studies have indicated the intracellular and intercellular crosstalk between exosomes and autophagy as two components of the eukaryotic endomembrane system. Exosomes are bilayer lipid membrane vesicles to participate in intercellular communication. Autophagy is to form autophagosome, then fuse with lysosome to degrade contents encapsulating cytoplasmic components. Exosomes and autophagy not only intersect through common molecular mechanism or organelle within cells, but also could activate intracellular autophagy-related signaling pathways to demonstrate the therapeutic potentiality of various diseases via exosomal miRNAs and proteins. The intracellular and intercellular crosstalk of them serves a homeostatic role in mitigating stress. What has become clear is that the steady state of this interaction is of great significance in physiology and pathology. If we could better understand the crosstalk from more perspectives, such as the function of exosomal lipids in regulating autophagy, the use of invertebrates as research models and the relationship between exosomes and selective autophagy of organelle-level, this represents an opportunity for treatment, especially the application of engineered exosomes.

   More at link.