Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, February 11, 2025

Effects of Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery in Early Stroke Patients: An fNIRS Study

 Th reason for this research was because you incompetently didn't know of all this earlier research! YOU'RE FIRED along with your mentors and senior researchers!

Didn't your competent? doctor start using this years ago? Or don't you have a functioning stroke doctor? Does your hospital even have such a machine?

Effects of Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery in Early Stroke Patients: An fNIRS Study

Provisionally accepted
Menghui Liu Menghui Liu Chunyan Wang Chunyan Wang Xinyi Li Xinyi Li Chunxiao Wan Chunxiao Wan *
  • Tianjin Medical University General Hospital, Tianjin, China

The final, formatted version of the article will be published soon.



    Objective: 

    To explore the recovery of upper limb motor function and the changes in cortical functional connectivity in patients with early subcortical small infarcts accompanied by severe upper limb motor dysfunction (PESSUM) after intermittent theta burst stimulation (iTBS) via functional near-infrared spectroscopy (fNIRS) and to explore the related mechanisms.

    Methods: 

    We enrolled 56 subcortical ischemic stroke patients with FMA-UE ≤28 and randomly assigned them to receive either genuine (TG, n=29) or sham (CG, n=23) iTBS plus standard rehabilitation over 8 days. fNIRS was used to monitor cerebral HbO, HbD, and HbT concentrations, and RSFC changes were analyzed. The FMA-UE and MBI scores were used to evaluate upper limb motor function and daily activities. Intergroup comparisons were conducted using independent samples t tests, whereas intragroup comparisons were performed using paired samples t tests or Mann-Whitney U tests. The trend of the RSFC changes was analyzed via repeated-measures Analysis of Variance(ANOVA).

    Results: 

    Both groups showed significant improvements in FMA-UE and MBI scores postintervention (P < 0.001). The TG had higher MBI scores than the CG (p = 0.005). fNIRS revealed accelerated cyclical changes in cortical activity in the TG. 

    Conclusion: 

    iTBS significantly improved motor function and daily living ability in stroke patients, supporting a role for iTBS in promoting neural repair by accelerating cortical recovery cycles. This study provides evidence that iTBS is an effective rehabilitation strategy poststroke.

    Keywords: fNIRS1, stroke2, Resting-state3, iTBS4, tms5

    Received: 10 Dec 2024; Accepted: 10 Feb 2025.

    Copyright: © 2025 Liu, Wang, Li and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunxiao Wan, Tianjin Medical University General Hospital, Tianjin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.     

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