Deans' stroke musings: In search of an anti-inflammatory drug for Alzheimer disease

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, December 22, 2021

In search of an anti-inflammatory drug for Alzheimer disease

You have a good chance of getting dementia, hopefully your doctor has protocols to prevent that.

Your risk of dementia, has your doctor told you of this?

1. A documented 33% dementia chance post-stroke from an Australian study? May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`

3. A 20% chance in this research. July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018

The latest here:

In search of an anti-inflammatory drug for Alzheimer disease

Nature Reviews Neurology volume 16, pages 131–132 (2020)Cite this article

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Evidence suggests that chronic neuroinflammation has an important role in the pathogenesis of Alzheimer disease. However, in a new clinical trial, the tetracycline antibiotic minocycline, which has anti-inflammatory properties, failed to delay disease progression in individuals with mild Alzheimer disease.

Refers to Howard, R. et al. Minocycline at 2 different dosages versus placebo for patients with mild Alzheimer disease: a randomized clinical trial. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2019.3762 (2019)

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