Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, January 7, 2022

Frontline thrombectomy strategy and outcome in acute basilar artery occlusion

You're not measuring 100% recovery which means  it's not important enough for you to solve. Maybe, just maybe you want to talk to your patients because you're forcing your tyranny of low expectations on them.  Survivors don't fucking care about revascularization, that's just the first step to 100% recovery. 

Business 101: If you don't measure it, it is not important, so obviously 100% recovery is not important. 

“What's measured, improves.” So said management legend and author Peter F. Drucker 

The latest here:

Frontline thrombectomy strategy and outcome in acute basilar artery occlusion

  1. Mohamed Abdelrady1,2,
  2. Julien Ognard2,
  3. Federico Cagnazzo1,
  4. Imad Derraz1,
  5. Pierre-Henri Lefevre1,
  6. Carlos Riquelme1,
  7. Gregory Gascou1,
  8. Caroline Arquizan3,
  9. Cyril Dargazanli1,
  10. Mourad Cheddad El Aouni2,
  11. Douraied Ben Salem4,
  12. Isabelle Mourand3,
  13. Vincent Costalat1,
  14. Jean Christophe Gentric2
  15. on behalf of RAMBO (Revascularization via Aspiration or Mechanical thrombectomy in Basilar Occlusion)
  1. Correspondence to Dr Mohamed Abdelrady, Interventional Neuroradiology, Hôpital Gui de Chauliac Pôle Neurosciences tête et cou, Montpellier 34295, Languedoc-Roussillon Midi, France; mmabdelrady@gmail.com

Abstract

Background Novel thrombectomy strategies emanate expeditiously day-by-day counting on access system, clot retriever device, proximity to and integration with the thrombus, and microcatheter disengagement. Nonetheless, the relationship between native thrombectomy strategies and revascularization success remains to be evaluated in basilar artery occlusion (BAO).

Purpose To compare the safety and efficacy profile of key frontline thrombectomy strategies in BAO.

Methods Retrospective analyses of prospectively maintained stroke registries at two comprehensive stroke centers were performed between January 2015 and December 2019. Patients with BAO selected after MR imaging were categorized into three groups based on the frontline thrombectomy strategy (contact aspiration (CA), stent retriever (SR), or combined (SR+CA)). Patients who experienced failure of clot retrieval followed by an interchanging strategy were categorized as a fourth (switch) group. Clinicoradiological features and procedural variables were compared. The primary outcome measure was the rate of complete revascularization (modified Thrombolysis in Cerebral Infarction (mTICI) grade 2c–3). Favorable outcome was defined as a 90 day modified Rankin Scale score of 0–2.

Results Of 1823 patients, we included 128 (33 underwent CA, 35 SR, 35 SR +CA, and 25 switch techniques). Complete revascularization was achieved in 83/140 (59%) primarily analyzed patients. SR +CA was associated with higher odds of complete revascularization (adjusted OR 3.04, 95% CI 1.077 to 8.593, p=0.04) which was an independent predictor of favorable outcome (adjusted OR 2.73. 95% CI 1.152 to 6.458, p=0.02). No significant differences were observed for symptomatic intracranial hemorrhage, functional outcome, or mortality rate.

Conclusion Among BAO patients, the combined technique effectively(What you have described is not effective, NO 100% RECOVERY!) contributed to complete revascularization that showed a 90 day favorable outcome with an equivalent complication rate after thrombectomy.

Data availability statement

Data are available upon reasonable request.

Statistics from Altmetric.com

Introduction

Following the results of recent landmark randomized trials, endovascular thrombectomy (EVT) has been validated as the standard of care for anterior circulation stroke (ACS).1 Stent retriever (SR) thrombectomy, which was employed in more than 80% of patients within the MR CLEAN (Multicenter Randomized Clinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands), EXTEND-IA (Extending the Time for Thrombolysis in Emergency Neurological Deficits-Intra-Arterial), ESCAPE (Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke), and SWIFT PRIME (Solitaire With the Intention For Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke) trials achieved a significantly greater rate (58–88%) of successful recanalization (modified Thrombolysis in Cerebral Infarction (mTICI) grade 2b/3) and a proportionate higher rate of functional independence (modified Rankin Scale (mRS) score of 0–2) in 53–71% of patients compared with those treated with intravenous thrombolysis only.2

The introduction of soft tipped, atraumatic, highly trackable large bore intermediate catheters prompted the evolution of contact aspiration (CA) as frontline therapy in ACS.3 Similar angiographic results, analogous outcome, and comparable safety endpoints between CA and SR thrombectomy that were demonstrated in the ASTER (Contact Aspiration vs Stent Retriever for Successful Revascularization) and COMPASS (Aspiration thrombectomy versus stent retriever thrombectomy as first-line approach for large vessel occlusion) trials empowered incorporation of aspiration thrombectomy in the therapeutic armamentarium of stroke.4 5

As shown by Kang et al, the switching strategy between CA and SR resulted in a higher overall rate of successful recanalization compared with patients without the switching strategy (85.1% vs 73.8%, respectively).6 Currently, simultaneous distal aspiration with SR thrombectomy (combined SR +CA) has been broadly adopted with variable terminology to enhance the technical outcome and reduce potential clot fragmentation and distal embolization.7–10

To our knowledge, there are no current comparative studies regarding the safety and efficacy of foregoing revascularization techniques, particularly in the setting of basilar artery occlusion (BAO). Furthermore, swapping between techniques was customarily deemed as a failure with no separate exploration of those patients. We, therefore, investigated the influence of the frontline EVT technique on complete revascularization and outcome in MRI selected patients with BAO.

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