Interesting, but will your doctor have the same interest AND create protocols on this for your risks of dementia?
Ebselen is referred to in the main section.
Ebselen, an anti-inflammatory antioxidant, was originally developed by Daiichi Sankyo, in Japan, to treat patients who had suffered a stroke. But the compound was never marketed and has since come off patent. It’s also part of the National Institutes of Health Clinical Collection—several hundred small molecules that have, to some extent, gone through the gamut of human clinical trials and have been found to be safe, but never reached final FDA approval.
ebselen (10 posts to December 2012)
Naturally Occurring Antioxidant Therapy in Alzheimer’s Disease
Andrila E. Collins , Tarek M. Saleh and Bettina E. Kalisch *
Department of Biomedical Sciences and Collaborative Specialization in Neuroscience Program, University of
Guelph, Guelph, ON N1G 2W1, Canada; andrila@uoguelph.ca (A.E.C.); tsaleh@uoguelph.ca (T.M.S.)
* Correspondence: bkalisch@uoguelph.ca
Abstract:
It is estimated that the prevalence rate of Alzheimer’s disease (AD) will double by the
year 2040. Although currently available treatments help with symptom management, they do not
prevent, delay the progression of, or cure the disease. Interestingly, a shared characteristic of AD
and other neurodegenerative diseases and disorders is oxidative stress. Despite profound evidence
supporting the role of oxidative stress in the pathogenesis and progression of AD, none of the
currently available treatment options address oxidative stress. Recently, attention has been placed on
the use of antioxidants to mitigate the effects of oxidative stress in the central nervous system. In
preclinical studies utilizing cellular and animal models, natural antioxidants showed therapeutic
promise when administered alone or in combination with other compounds. More recently, the
concept of combination antioxidant therapy has been explored as a novel approach to preventing and
treating neurodegenerative conditions that present with oxidative stress as a contributing factor. In
this review, the relationship between oxidative stress and AD pathology and the neuroprotective role
of natural antioxidants from natural sources are discussed. Additionally, the therapeutic potential of
natural antioxidants as preventatives and/or treatment for AD is examined, with special attention
paid to natural antioxidant combinations and conjugates that are currently being investigated in
human clinical trials.
More at link.
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