Key PointsQuestion
What is the cost-effectiveness of exercise or cognitive and
social enrichment activities to improve cognition among older adults
with chronic stroke?
Findings
In this economic evaluation with 120 older adults from a
randomized clinical trial, the multicomponent exercise program conducted
over a 6-month period was cost-effective for cognitive function, with
limited impact on health-related quality of life. Cognitive and social
enrichment activities incurred higher costs compared with the balance
and tone control group.
Meaning
These findings suggest that multicomponent exercise may be a
cost-effective approach to improving cognitive function in older adults
with chronic stroke.
Importance
Cognitive impairment is prevalent in survivors of stroke,
affecting approximately 30% of individuals. Physical exercise and
cognitive and social enrichment activities can enhance cognitive
function in patients with chronic stroke, but their cost-effectiveness
compared with a balance and tone program is uncertain.
Objective
To conduct a cost-effectiveness and cost-utility analysis of
multicomponent exercise or cognitive and social enrichment activities
compared with a balance and tone program.
Design, Setting, and Participants
This economic evaluation used a Canadian health care systems
perspective and the Vitality study, a randomized clinical trial aimed at
improving cognition after stroke with a 6-month intervention and a
subsequent 6-month follow-up (ie, 12 months). The economic evaluation
covered the duration of the Vitality trial, between June 6, 2014, and
February 26, 2019. Participants were community-dwelling adults aged 55
years and older who experienced a stroke at least 12 months prior to
study enrollment in the Vancouver metropolitan area, British Columbia,
Canada. Data were analyzed from June 1, 2022, to March 31, 2023.
Interventions
Participants were randomly assigned to twice-weekly classes
for 1 of the 3 groups: multicomponent exercise program, cognitive and
social enrichment activities program, or a balance and tone program
(control).
Main Outcomes and Measures
The primary measures for the economic evaluation included
cost-effectiveness (incremental costs per mean change in cognitive
function, evaluated using the Alzheimer Disease Assessment
Scale–Cognitive-Plus), cost-utility (incremental cost per
quality-adjusted life-year gained), intervention costs, and health care
costs. Since cognitive benefits 6 months after intervention cessation
were not observed in the primary randomized clinical trial, an economic
evaluation at 12 months was not performed.
Results
Among 120 participants (mean [SD] age, 71 [9] years; 74 [62%]
male), 34 were randomized to the multicomponent exercise program, 34
were randomized to the social and cognitive enrichment activities
program, and 52 were randomized to the balance and tone control program.
At the end of the 6-month intervention, the cost per mean change in
Alzheimer Disease Assessment Scale–Cognitive-Plus score demonstrated
that exercise was more effective and costlier compared with the control
group in terms of cognitive improvement with an incremental
cost-effectiveness ratio of CAD −$8823. The cost per quality-adjusted
life-year gained for both interventions was negligible, with exercise
less costly (mean [SD] incremental cost, CAD −$32 [$258]) and cognitive
and social enrichment more costly than the control group (mean [SD]
incremental cost, CAD $1018 [$378]). The balance and tone program had
the lowest delivery cost (CAD $777), and the exercise group had the
lowest health care resource utilization (mean [SD] $1261 [$1188]) per
person.
Conclusions and Relevance
The findings of this economic evaluation suggest that exercise
demonstrated potential for cost-effectiveness to improve cognitive
function in older adults with chronic stroke during a 6-month
intervention.