Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 21, 2022

New blood biomarker may lead to early diagnosis of frontotemporal dementia

You'll expect your doctor to have this test for you post stroke. If not you don't have a doctor at all. Then after diagnosis of this you'll need EXACT DEMENTIA PREVENTION PROTOCOLS!  No excuses allowed, your doctor is responsible for those protocols. 

Your risks of dementia, has your doctor told you of this?

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018

Where are the  protocols to prevent your dementia?

The latest here:

New blood biomarker may lead to early diagnosis of frontotemporal dementia

A collaboration between Mayo Clinic researchers and a team dedicated to researching frontotemporal dementia has identified neurofilament light as a useful biomarker for the disease.

“There is at present no truly effective treatment for patients with [frontotemporal dementia (FTD)],” Tania Gendron, PhD, a neuroscientist at the Mayo Clinic and corresponding author of the study, said a Mayo Clinic press release. “It's believed that potential treatments will be most beneficial to individuals when administered early in the disease course — soon after symptom onset or ideally even before symptom onset.

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Source: Adobe Stock.

“Unfortunately, this is not always possible, because there are often delays in diagnosing FTD, and there are still no confirmed means to predict when someone may begin to develop symptoms.”

According to a paper published in Cell Reports Medicine, Gendron and colleagues in the Advancing Research and Treatment in Frontotemporal Lobar Degeneration and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects studies (ALLFTD Consortium) measured plasma neurofilament light protein in a large cohort of nearly 1,000 participants, which included healthy individuals, people with a gene mutation that causes FTD and people with FTD syndrome.

Researchers found elevated levels of plasma neurofilament light protein in patients with FTD, as well as in asymptomatic people with mutations, and noted that higher levels of neurofilament light were associated with greater disease severity. They also identified elevated levels of the protein just before people became symptomatic.

According to Gendron and colleagues, their findings may improve the design of future clinical trials and inform other areas of research on neurodegenerative diseases, with neurofilament light serving as a biomarker for many of those diseases.

“Through this study, we have created a major informational database comprising cross-sectional and longitudinal [neurofilament light]data, along with demographic, genetic, clinical and neuropsychological data,” Leonard Petrucelli, PhD, a Mayo Clinic neuroscientist and corresponding author on the study, said in the release.

References:

 

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