In what multiverse do you live if you think this will get to your hospital if all these earlier ones didn't make it?
vagus nerve (56 posts to July 2012)
Paired vagus nerve stimulation for treatment of upper extremity impairment after stroke
Abstract
The use of a paired vagus nerve stimulation (VNS) system for the treatment of moderate to severe upper extremity motor deficits associated with chronic ischaemic stroke has recently been approved by the U.S Food and Drug Administration. This treatment aims to increase task specific neuroplasticity through activation of cholinergic and noradrenergic networks during rehabilitation therapy. A recent pivotal phase III trial showed that VNS paired with rehabilitation led to improvements in upper extremity impairment and function in people with moderate to severe arm weakness an average of three years after ischaemic stroke. The between group difference following six weeks of in-clinic therapy and 90 days of home exercise therapy was three points on the upper extremity Fugl Meyer score. A clinically meaningful response defined as a greater than or equal to six point improvement was seen in approximately half of people treated with VNS compared to approximately a quarter of people treated with rehabilitation alone. Further post-marketing research should aim to establish whether the treatment is also of use for people with intracerebral haemorrhage, in people with more severe arm weakness, and for other post stroke impairments. In addition, high quality randomised studies of non-invasive VNS are required.
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