Deans' stroke musings: Targeted drug delivery to the brain and brain tumors using focused ultrasound and microbubbles

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, November 9, 2013

Targeted drug delivery to the brain and brain tumors using focused ultrasound and microbubbles

The targeting piece sounds very important to position drugs in the right location whenever we do find out how to stop the neuronal cascade of death.
http://europepmc.org/abstract/MED/24181339
McDannold N

Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MAnjm@bwh.harvard.edu.

The Journal of the Acoustical Society of America [2013, 134(5):4089]

Type: Journal Article
DOI: 10.1121/1.4830934

Abstract

Highlight Terms

Gene Ontology(1) Diseases(3) Species(1) Chemicals(2)

The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, severely limits the delivery of most drugs to the brain and to brain tumors. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets and enhance delivery across the "blood-tumor barrier." This talk aims to provide insight on the current status of this unique drug delivery technique, experience with it in preclinical models, and its potential for clinical translation. In particular, methods to monitor the procedure using acoustic receivers and the feasibility of controlling and predicting drug deposition will be reviewed. If this method, which offers a flexible means to target therapeutics to desired points or volumes in the brain, can be translated to the use in humans, it can enable the use of the whole arsenal of drugs in the CNS that are currently prevented by the BBB