Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 21, 2023

Adequate hydration may slow biological aging, reduce disease risk

 Another protocol for your doctor to have in place to make sure you leave the hospital better than you came in. 

Which means you probably need to be catheterized or diapered immediately in the hospital. There aren't enough nurses to get all their patients safely to the bathroom in time. When I'm traveling, especially on airplanes and buses, I purposely stay dehydrated in order not to need to use the bathroom.

Due to the nature of sodium's chemistry, it cannot be tested by a simple test kit method.

Your doctor's responsibility to test this on you. 

On coffee:

The caffeine in coffee gives it diuretic effects, meaning it causes your body to pass more urine. But these effects are too mild to cause dehydration, especially if you're a regular coffee drinker. Coffee may even be hydrating for some people, because it contains a lot of water.

On alcohol:

For reference, a standard drink—12 ounces of beer, 5 ounces of wine, 1.5 ounces of liquor—has 14 grams of alcohol, according to the National Institute on Alcohol Abuse and Alcoholism [3]. In other words, the alcohol alone in one standard drink can make your body produce a little less than half a cup of pee

So to calculate; a standard 5 ounce glass of wine produces less than 4 ounces of pee. That doesn't sound like dehydration.  Beer would make even better sense.

 The latest here:

Adequate hydration may slow biological aging, reduce disease risk

Adults with elevated serum sodium in middle age, a marker of inadequate fluid intake, were more likely to be biologically older than their chronological age and develop chronic diseases compared with adequately hydrated adults, data show.

“There has been a shift in thinking about the roles of good hydration,” Natalia Dmitrieva, PhD, senior research scientist in the Laboratory of Cardiovascular Regenerative Medicine at the NHLBI, told Healio. “Traditionally, the focus has been on short-term effects of big water losses that occur, for example, during prolonged exercise or exposure to heat. In recent years, a growing number of epidemiological studies show links between poor hydration and adverse long-term health outcomes such as HF, diabetes and kidney function decline, and now also with chronic diseases in general and premature mortality.”

old people exercising
Source: Adobe Stock

Dmitrieva and colleagues analyzed data from 15,752 middle-aged adults aged 45 to 66 years at baseline who participated in the ongoing Atherosclerosis Risk in Communities study and were followed for 25 years. Researchers assessed serum sodium as a proxy for hydration habits and estimated the relative speed of aging by calculating biological age, using age-dependent biomarkers and assessing risk for chronic diseases and premature mortality.

Researchers found that a serum sodium of more than 142 mmol/L in middle age was associated with a 39% increased risk for developing chronic diseases (HR = 1.39; 95% CI, 1.18-1.63), whereas a serum sodium of more than 144 mmol/L was associated with a 21% elevated risk for premature mortality (HR = 1.21; 95% CI, 1.02-1.45).

Participants with serum sodium of more than 142 mmol/L were up to twice as likely to be biologically older than their chronological age (OR = 1.5; 95% CI, 1.14-1.96). A higher biological age was associated with an increased risk for chronic diseases, including HF, dementia, chronic lung disease, stroke, diabetes, peripheral vascular disease and atrial fibrillation (HR = 1.7; 95% CI, 1.5-1.93), as well as premature mortality (HR = 1.59; 95% CI, 1.39-1.83), according to the researchers.

Dmitrieva said people whose serum sodium is 142 mEq/L or higher would benefit from evaluation of their fluid intake..

“The links from the observational epidemiological studies need to be confirmed in interventional trials,” Dmitrieva told Healio. “The next step for this research would be to test whether improved hydration can indeed slow down the aging process and improve health outcomes.”

“On the global level, this can have a big impact,” Dmitrieva said in a press release. “Decreased body water content is the most common factor that increases serum sodium, which is why the results suggest that staying well hydrated may slow down the aging process and prevent or delay chronic disease.”

Perspective

Back to Top Deepak L. Bhatt, MD, MPH)

Deepak L. Bhatt, MD, MPH

These findings are in line with advice many people around the world received when they were young — drink six to eight glasses of water every day. For many years, that advice went in and out of vogue. This study does pass the common-sense test that staying well hydrated is probably a good idea. Whether doing that or simply drinking whenever you are thirsty makes a real difference is unclear. Where this can fall apart is with older adults or those with clinical or subclinical dementia, when a person can lose their sense of thirst. There, it is important to make the extra effort to make sure vulnerable people stay hydrated.

This analysis included middle-aged people aged 45 to 66 years, so dementia is likely not a major factor. The only way to prove this observational analysis is to conduct a proper randomized trial comparing different degrees of water intake. That would be inexpensive because water is inexpensive; however, dietary trials are notoriously difficult and the cohort would need to be large to see any measurable effect size.

As a standard part of a lab draw, clinicians always get a sodium level, so if someone’s sodium level is off, a clinician would act on it. If the sodium level is only in the high-normal range, I don’t know if a clinician would necessarily act on that and try to include water intake as part of an already busy clinic visit. From a lay person’s practical perspective, it makes sense to stay well hydrated in life. Should you force yourself to drink even if you are not thirsty? I’m not sure I endorse that; however, in this peripandemic era where many people may work from home and live a more sedentary lifestyle, it is important not to lose track of staying well hydrated.

Deepak L. Bhatt, MD, MPH
Cardiology Today Intervention Section Editor
Director, Mount Sinai Heart
Dr. Valentin Fuster Professor of Cardiovascular Medicine
The Icahn School of Medicine at Mount Sinai
Disclosures: Bhatt reports various financial ties with various pharmaceutical and device companies.

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