Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 19, 2026

High relative cerebral blood volume strongly predicts early neurological improvement and good functional outcome in ischemic stroke patients undergoing mechanical thrombectomy

 Are these a solution? You mean your incompetent? doctor and hospital have nothing to deliver better blood flow and oxygen to your brain immediately post stroke! And your board of directors is so incompetent they don't recognize incompetence in their hospital?

  • cerebral blood flow (51 posts to December 2015)
  • oxygen delivery (41 posts to June 2016)

    • High relative cerebral blood volume strongly predicts early neurological improvement and good functional outcome in ischemic stroke patients undergoing mechanical thrombectomy


    Paweł Wrona, Dominik Wróbel, Julia Staniszewska, Gabriela Kapral, Milena Derechowska, Gabriela Turaj, Tadeusz Popiela, Agnieszka Słowik, Wojciech Turaj
    DOI: 10.5603/pjnns.106870
    Pubmed: 41705962

    Abstract

    Aim of the study. Despite advancements in mechanical thrombectomy (MT) in the treatment of acute ischemic stroke (AIS) due to large vessel occlusion, nearly half of patients with successful recanalization do not achieve good functional outcome (GFO). We aimed to analyze the association between novel perfusion-based biomarkers and prognosis after AIS.Clinical rationale for the study. The role of perfusion imaging biomarkers, particularly relative cerebral blood volume (rCBV), as an indicator of tissue-level collateral circulation and a predictor of post-MT clinical trajectory remains insufficiently explored.

    Material and methods. This single-center retrospective study included patients with anterior circulation AIS who achieved successful recanalization following MT at the Comprehensive Stroke Center, University Hospital, Krakow, between January 2019 and July 2023. We evaluated the predictive value of rCBV for early neurological improvement (ENI) and long-term GFO and compared its prognostic utility with other perfusion-based parameters. Furthermore, we assessed the extent to which the effect of rCBV on GFO was mediated by its influence on ENI. Early neurological improvement was defined as a ≥ 4-point reduction in the National Institutes of Health Stroke Scale score or complete symptom resolution within 24 hours post-admission. GFO was defined as a modified Rankin Scale score of < 3 at 90 days.

    Results. Relative cerebral blood volume was an independent predictor of 90-day GFO after multivariable adjustment (adjusted odds ratio [aOR] = 1.38; 95% confidence interval [CI]: 1.19–1.6; p < 0.001). Additionally, total hypoperfusion volume (T6max) independently contributed to GFO prediction when included alongside rCBV (aOR = 0.96 per 10 mL increase; 95% CI: 0.94–0.99; p = 0.019), enhancing prognostic accuracy. Relative cerebral blood volume was also a strong predictor of ENI (aOR = 1.35; 95% CI: 1.19–1.54; p < 0.001), with 35% (4–67%; p = 0.029) of its effect on GFO mediated through its impact on ENI.

    Conclusion and clinical implications. Relative cerebral blood volume is a robust predictor of both early neurological recovery and long-term functional outcome following MT. Moreover, T6max provides independent prognostic value when assessed in conjunction with rCBV, suggesting that these parameters complement each other. Their combined assessment provides a more comprehensive understanding of ischemic tissue fate, aiding clinical decision-making in patients selected for MT.

    (My conclusion, you completely failed in your research; DIDN'T CREATE A PROTOCOL TO DELIVER THE BETTER BLOOD FLOW!)

    Keywords: mechanical thrombectomycomputed tomography perfusionacute ischemic strokerelative cerebral blood volume

    Article available in PDF format

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