Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, February 23, 2026

Turning the tide in stroke recovery: IGF-2 as a driver of neuroprotection, angiogenesis and neurogenesis.

Your advisors incompetently didn't know of all this earlier research AND DIDN'T KNOW OF YOUR RESPONSIBILITY TO CREATE STROKE REHAB PROTOCOLS FROM THAT?

I don't care if you are still a student, the real world requires creation of EXACT REHAB PROTOCOLS, at least if you are being trained correctly!

  • angiogenesis (143 posts to April 2011)
  • neuroprotection (333 posts to March 2011)
  • neurogenesis (635 posts to September 2010)

    •  Turning the tide in stroke recovery: IGF-2 as a driver of neuroprotection, angiogenesis and neurogenesis.

    Authors: ALDERS, Lotte 
    Advisors: Bronckaers, Annelies
    Wolfs, Esther
    Issue Date: 2026
    Abstract: Stroke remains one of the leading causes of death and long-term disability worldwide, and despite advances in acute care, therapeutic options remain severely limited. The currently approved treatments, including reperfusion therapies with intravenous thrombolysis or endovascular thrombectomy, are constrained by narrow therapeutic windows, strict eligibility criteria, and limited accessibility. As a result, the majority of patients remain untreated and are left with permanent neurological impairments. This reality underscores the urgent need for new therapeutic approaches that not only preserve brain tissue immediately after stroke but also actively support long-term repair and recovery. Within this context, insulin-like growth factor 2 (IGF-2), traditionally known for its role in fetal growth and development, has emerged as a promising candidate. Unlike IGF-1, IGF-2 remains abundant in the adult brain, suggesting it may play a role in central nervous system maintenance and repair. This dissertation has four main aims to advance stroke research: 1) to evaluate the neuroprotective effects of IGF-2 and Des(1-6)IGF-2 on infarct size, 2) to investigate their impact on post-stroke neuroinflammation, 3) to examine their role in promoting angiogenesis in vitro and in ovo, and 4) to assess their effects on neural stem cell proliferation and migration. The overall goal is to clarify how IGF-2 and its analogs contribute to brain protection and brain repair.
    Document URI: http://hdl.handle.net/1942/48558
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