You'll need your competent? doctor and hospital to get human testing going so they can objectively identify your brain inflammation and come up with ways to prevent it.
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Low-Power-Activated Afterglow Nanoprobes With Naked-Eye Visibility for High-Contrast Imaging of Brain Inflammation
PDFABSTRACT
Afterglow luminescence imaging ingeniously circumvents the need for real-time excitation, thereby substantially eliminating background interference. Nevertheless, its application in brain imaging has been hindered by low afterglow brightness under aqueous conditions. Here, we present naked-eye-visible afterglow nanoprobes excited by low-power light for high-contrast imaging of brain inflammation. By strategically integrating highly efficient donor–acceptor–donor (D–A–D) luminescent molecules into photochemical afterglow systems, we developed a series of ultrabright afterglow materials emitting in the yellow, orange, and red spectral regions. The resulting afterglow nanoparticles remain naked-eye detectable even under ultralow excitation power (0.73 mW cm−2). Their afterglow brightness is over 1300 times higher than that of commonly used afterglow nanoparticles, and they still maintain a 3-fold advantage compared to previously developed blue-emitting nanoparticles based on molecular fusion strategies. Leveraging this exceptional performance, we accomplished real-time naked-eye observation of freely moving mice. Moreover, macrophage-encapsulated nanoparticles enabled blood–brain barrier (BBB) penetration and high-contrast imaging of brain inflammation. This work introduces a new paradigm for constructing high-brightness afterglow materials and opens transformative avenues for real-time visualization of brain disorders.
Graphical Abstract
By integrating D–A–D molecules into photochemical afterglow systems, we developed nanoprobes exhibiting naked-eye-detectable afterglow under low-power excitation (0.73 mW cm−2). Their brightness is 1305 times higher than that of common afterglow nanoparticles such as MEHPPV-NPs, enabling naked-eye tracking of freely moving mice and high-contrast imaging of brain inflammation.
Conflicts of Interes
The authors declare no conflicts of interest.
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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