http://circinterventions.ahajournals.org/content/9/11/e004571.extract?etoc
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- Editorials
- complications
- coronary atherectomy
- drug-eluting stent
- plaque modification
- rotational atherectomy
Unlike
balloon dilation that results in the displacement of atherosclerotic
plaque with multiple intimal tears, rotational atherectomy (RA) is based
on the principle of differential cutting that allows for physical
removal of inelastic atherosclerotic material while rendering the inner
lumen surface smooth.1
Although plaque reduction by pulverization of atherosclerotic material
into <10 µm particles has remained its central paradigm,2
the conceptual framework has shifted from the original approach of RA
as a debulking strategy and, thus, applicable in a broad array of
coronary lesions with large plaque burden, to a contemporary selective
clinical utilization, with an emphasis mainly on plaque modification
prior to stent implantation.3,4
This transition in conceptual understanding of the targeted effects of
RA has been mirrored by a decreasing tendency in its use, from 20% in
the mid 1990s to 1% to 3% according to contemporary reports.4,5
Today, RA is used selectively, mainly to disrupt the continuity of the
calcium ring within the vessel wall and, thus, facilitate optimal
drug-eluting stent (DES) implantation in patients with severely
calcified de novo coronary lesions. ROTAXUS (Rotational Atherectomy
Prior to Taxus Stent Treatment for Complex Native Coronary Artery
Disease), as the only randomized trial to date that tested the strategy
of routine lesion preparation with RA followed by DES implantation
against stenting without RA, showed a higher rate of procedural success
in patients undergoing RA, which, however, did not translate in
long-term clinical benefit.6 These findings coincided with previous nonrandomized studies that had also supported RA …
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