Since your hospital doesn't have a research analyst the results of this study will never get distributed to doctors and then down to patients. So useless research since nothing will occur because of it.
Harnessing Neuroplasticity to Promote Brain Health in Aging Adults: Protocol for the MOVE-Cog Intervention Study
Abstract
Background:
Extensive
evidence supports a link between aerobic exercise and cognitive
improvements in aging adults. A major limitation with existing research
is the high variability in cognitive response to exercise. Our
incomplete understanding of the mechanisms that influence this
variability and the low adherence to exercise are critical knowledge
gaps and major barriers for the systematic implementation of exercise
for promoting cognitive health in aging.
Objective:
We
aimed to provide an in-person and remotely delivered intervention study
protocol with the main goal of informing the knowledge gap on the
mechanistic action of exercise on the brain by characterizing important
mechanisms of neuroplasticity, cardiorespiratory fitness response, and
genetics proposed to underlie cognitive response to exercise.
Methods:
This
is an open-label, 2-month, interventional study protocol in
neurologically healthy sedentary adults. This study was delivered fully
in-person and in remote options. Participants underwent a total of 30
sessions, including the screening session, 3 pretest (baseline)
assessments, 24 moderate-to-vigorous aerobic exercise sessions, and 3
posttest assessments. We recruited participants aged 55 years and above,
sedentary, and cognitively healthy. Primary outcomes were
neuroplasticity, cognitive function, and cardiorespiratory fitness.
Secondary outcomes included genetic factors, endothelium function,
functional mobility and postural control, exercise questionnaires,
depression, and sleep. We also explored study feasibility, exercise
adherence, technology adaptability, and compliance of both in-person and
remote protocols.
Results:
The
recruitment phase and data collection of this study have concluded.
Results are expected to be published by the end of 2021 or in early
2022.
Conclusions:
The
data generated in these studies will introduce tangible parameters to
guide the development of personalized exercise prescription models for
maximal cognitive benefit in aging adults. Successful completion of the
specific aims will enable researchers to acquire the appropriate
expertise to design and conduct studies by testing personalized exercise
interventions in person and remotely delivered, likely to be more
effective at promoting cognitive health in aging adults.
Trial Registration: ClinicalTrials.gov NCT03804528; http://clinicaltrials.gov/ct2/show/NCT03804528
International Registered Report Identifier (IRRID): RR1-10.2196/33589
doi:10.2196/33589
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