Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, November 15, 2021

How Nicotine Influences Hippocampal Dependent Cognition

Hasn't this been known for years? And isn't your doctor prescribing nicotine immediately post stroke?

I'm going to do the nicotine patches for my next stroke even though I have no clue on dosage.  Don't listen to me with no medical training. Is your doctor trained in the latest research? Say the last 20 years?

 

How is your doctor having your nicotine delivered? 

Too bad the nicotine gum got cancelled.

 

So I guess I'll have to do patches for my nicotine needs post stroke.


Nicotine Holds Promise for Stronger Stroke Recovery

 

Nicotine Patch Appears To Help Mild Cognitive Loss

 

Can nicotine protect the aging brain?

This Legal Drug Could Protect Brain From Ageing - Nicotine

 The latest here:

 

How Nicotine Influences Hippocampal Dependent Cognition

 

Summary: Nicotine exposure significantly altered the metabolism and secretion of serotonin, acetylcholine, kynurenic acid, and choline in HT22 hippocampal cells. Findings suggest nicotine could have neuroprotective properties and provide cognitive enhancement.

Source: Chinese Academy of Sciences

Nicotine ingested from smoking exerts neuroprotection and developmental neurotoxicity in the central nervous system. It can produce changes of cognitive behaviors through regulating the release of different neurotransmitters in the brain.

However, the effects of nicotine exposure or withdrawal on neurotransmitter metabolism of hippocampal neurons still remain unclear.

Dr. Luo Qian’s group from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences has revealed the possible mechanism of nicotine on hippocampal-dependent cognition.

Their study was published in Chinese Chemical Letters on Sept. 24.

Through a microfluidic chip coupled with liquid chromatography-mass spectrometry (MC-LC-MS) system, the researchers used mice in real-time to evaluate the dynamic alterations induced by nicotine exposure and withdrawal at relevant exposure levels of smoking and secondhand smoke in the neurotransmitter metabolism of hippocampal neuron (HT22) cells.

This shows a brain
These results suggested the acute exposure to nicotine was beneficial to protect the neurons, especially cognitive enhancement, and the elevated picolinic acid continually protected neuronal cognitive function after nicotine withdrawal. Image in the public domain

The MC-LC-MS system showed an advantage in detecting unstable metabolites over the conventional method of using in vitro model. “We found that HT22 cells mainly released related neurotransmitters of tryptophan and choline metabolism,” said Dr. Luo.

Moreover, exposure to nicotine at relevant levels of smoking and secondhand smoke significantly altered the metabolism and secretion of serotonin, kynurenic acid, choline and acetylcholine of HT22 cells, and their alterations were closely associated with the exposure dose and duration.

These results suggested the acute exposure to nicotine was beneficial to protect the neurons, especially cognitive enhancement, and the elevated picolinic acid continually protected neuronal cognitive function after nicotine withdrawal.

Furthermore, the dynamic alterations of neurotransmitter metabolism induced by nicotine might be a possible protective mechanism of nicotine on hippocampal dependent cognition.

About this neuroscience research news

Author: Press Office
Source: Chinese Academy of Sciences
Contact: Press Office – Chinese Academy of Sciences
Image: The image is in the public domain

Original Research: Closed access.
“Real-time effects of nicotine exposure and withdrawal on neurotransmitter metabolism of hippocampal neuronal cells by microfluidic chip-coupled LC-MS” by Zhiyu Chen et al. Chinese Chemical Letters

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