http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10391689&fileId=S0954422416000081
Christine Heberden
Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France
Abstract
Three
areas in the brain continuously generate new neurons throughout life:
the subventricular zone lining the lateral ventricles, the dentate gyrus
in the hippocampus and the median eminence in the hypothalamus. These
areas harbour neural stem cells, which contribute to neural repair by
generating daughter cells that then become functional neurons or glia.
Impaired neurogenesis leads to detrimental consequences, such as
depression, decline of cognitive abilities and obesity. Adult
neurogenesis is a versatile process that can be modulated either
positively or negatively by many effectors, external or endogenous. Diet
can modify neurogenesis both ways, either directly by ways of
food-borne molecules, or possibly by the modifications induced on gut
microbiota composition. It is therefore critical to define dietary
strategies optimal for the maintenance of the stem cell pools.
Key words
- Neurogenesis;
- Neural stem cells;
- Brain
Abbreviations
- AMPK:AMP-activated protein kinase;
- ARC:arcuate nucleus;
- BDNF:brain-derived neurotrophic factor;
- CA:cornu Ammonis;
- CREB:cAMP response element binding protein;
- DG:dentate gyrus;
- ME:median eminence;
- NSC:neural stem cells;
- POMC:pro-opiomelanocortin;
- Sirt1:sirtuin 1;
- SVZ:subventricular zone
Correspondence
Corresponding author: Christine Heberden, email Christine.heberden@jouy.inra.fr
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