Abstract
Background.
Camera technique–based mirror visual feedback (MVF) is an optimal
interface for mirror therapy. However, its efficiency for stroke
rehabilitation and the underlying neural mechanisms remain unclear.
Objective.
To investigate the possible treatment benefits of camera-based MVF
(camMVF) for priming prior to hand function exercise in subacute stroke
patients, and to reveal topological reorganization of brain network in
response to the intervention.
Methods. Twenty subacute stroke
patients were assigned randomly to the camMVF group (MG, N = 10) or a
conventional group (CG, N = 10). Before, and after 2 and 4 weeks of
intervention, the Fugl-Meyer Assessment Upper Limb subscale (FMA_UL),
the Functional Independence Measure (FIM), the modified Ashworth Scale
(MAS), manual muscle testing (MMT), and the Berg Balance Scale (BBS)
were measured. Resting-state electroencephalography (EEG) signals were
recorded before and after 4-week intervention.
Results. The MG
showed more improvements in the FMA_UL, the FMA_WH (wrist and hand), and
the FIM than the CG. The clustering coefficient (CC) of the resting EEG
network in the alpha band was increased globally in the MG after
intervention but not in the CG. Nodal CC analyses revealed that the CC
in the MG tended to increase in the ipsilesional occipital and temporal
areas, and the bilateral central and parietal areas, suggesting improved
local efficiency of communication in the visual, somatosensory, and
motor areas. The changes of nodal CC at TP8 and PO8 were significantly
positively correlated with the motor recovery.
Conclusions. The
camMVF-based priming could improve the motor recovery, daily function,
and brain network segregation in subacute stroke patients.
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