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Genetic Variants May Influence Post-Stroke Recovery
Genes
may have a bearing not only on stroke risk, but also on how well
patients recover after stroke, according to a study published in Neurology.
For the first time, researchers have identified common genetic variants that are associated with outcome after ischaemic stroke.
For the study, Martin Söderholm, MD, Lund University, Lund, Sweden, and colleagues conducted a meta-analysis of 12 international stroke studies that included 6,165 patients with ischaemic stroke.
The patients were divided into 2 groups depending on their outcome at 3 months after ischaemic stroke -- 1 group was composed of patients who died and those who were dependent on help from others to cope with activities of daily living. The other group consisted of patients who were able to cope unaided 3 months after stroke.
By comparing analyses of the patients’ genomes, the researchers were able to find several different genetic variants that appear to have played a part in the patients’ outcomes.
“One of the common genetic variants we found was significant -- that is, clearly associated with a worse outcome in the large volumes of data we were able to access,” said Annie Pedersen, University of Gothenburg, Gothenburg, Sweden.
That variation, identified as rs1842681 in the LOC105372028 gene, can be linked to another gene that is part of a major process involved in brain plasticity.
The study took into account several other factors -- age, sex, and the extent of each patient’s brain damage -- that can also affect outcome after stroke. After adjustment for these factors, the association remained between the genetic variant and elevated risk of being in the group of patients who still, 3 months after the stroke onset, were unable to manage without assistance.
“Even if 2 patients seem to have the same prospects of recovering, their outcomes can be different,” said Pederson.
“Our limited knowledge of why some patients recover well while others incur lasting functional impairments after the same type of stroke has made it difficult to develop new treatment methods,” added Christina Jern, MD, University of Gothenburg.
“In the long run, we hope the research may enable us to identify new targets for medication that might help to improve post-stroke outcome, but there is a lot of research to be done before we get there,” she concluded.
Reference: https://doi.org/10.1212/WNL.0000000000007138
SOURCE: University of Gothenburg
For the first time, researchers have identified common genetic variants that are associated with outcome after ischaemic stroke.
For the study, Martin Söderholm, MD, Lund University, Lund, Sweden, and colleagues conducted a meta-analysis of 12 international stroke studies that included 6,165 patients with ischaemic stroke.
The patients were divided into 2 groups depending on their outcome at 3 months after ischaemic stroke -- 1 group was composed of patients who died and those who were dependent on help from others to cope with activities of daily living. The other group consisted of patients who were able to cope unaided 3 months after stroke.
By comparing analyses of the patients’ genomes, the researchers were able to find several different genetic variants that appear to have played a part in the patients’ outcomes.
“One of the common genetic variants we found was significant -- that is, clearly associated with a worse outcome in the large volumes of data we were able to access,” said Annie Pedersen, University of Gothenburg, Gothenburg, Sweden.
That variation, identified as rs1842681 in the LOC105372028 gene, can be linked to another gene that is part of a major process involved in brain plasticity.
The study took into account several other factors -- age, sex, and the extent of each patient’s brain damage -- that can also affect outcome after stroke. After adjustment for these factors, the association remained between the genetic variant and elevated risk of being in the group of patients who still, 3 months after the stroke onset, were unable to manage without assistance.
“Even if 2 patients seem to have the same prospects of recovering, their outcomes can be different,” said Pederson.
“Our limited knowledge of why some patients recover well while others incur lasting functional impairments after the same type of stroke has made it difficult to develop new treatment methods,” added Christina Jern, MD, University of Gothenburg.
“In the long run, we hope the research may enable us to identify new targets for medication that might help to improve post-stroke outcome, but there is a lot of research to be done before we get there,” she concluded.
Reference: https://doi.org/10.1212/WNL.0000000000007138
SOURCE: University of Gothenburg
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