Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,120 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Friday, April 5, 2019
Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice
Now we just need our stroke medical professionals to do human research and write a protocol on this along with the protocol for stroke recovery using vagus nerve stimulation. Here is the research on vagus nerve rehab in case your doctor is unfamiliar with it.
Inflammation
is a critical determinant of aneurysmal wall destabilization, growth,
and rupture risk. Targeting inflammation may suppress aneurysm rupture.
Vagus nerve stimulation (VNS) has been shown to suppress inflammation
both systemically and in the central nervous system. Therefore, we
tested the effect of a novel noninvasive transcutaneous VNS approach on
aneurysm rupture and outcome in a mouse model of intracranial aneurysm
formation with wall inflammation.
Methods—
Aneurysms
were induced by a single stereotaxic injection of elastase into the
cerebrospinal fluid at the skull base, combined with systemic
deoxycorticosterone-salt hypertension, without or with high-salt diet,
for mild or severe outcomes, respectively. Cervical VNS (two 2-minute
stimulations 5 minutes apart) was delivered once a day starting from the
day after elastase injection for the duration of follow-up.
Transcutaneous stimulation of the femoral nerve (FNS) served as control.
Multiple aneurysms developed in the circle of Willis and its major
branches, resulting in spontaneous ruptures and subarachnoid hemorrhage,
neurological deficits, and mortality.
Results—
In
the milder model, VNS significantly reduced aneurysm rupture rate
compared with FNS (29% versus 80%, respectively). Subarachnoid
hemorrhage grades were also lower in the VNS group. In the more severe
model, both VNS and FNS arms developed very high rupture rates (77% and
85%, respectively). However, VNS significantly improved the survival
rate compared with FNS after rupture (median survival 13 versus 6 days,
respectively), without diminishing the subarachnoid hemorrhage grades.
Chronic daily VNS reduced MMP-9 (matrix metalloproteinase-9) expression
compared with FNS, providing a potential mechanism of action. As an
important control, chronic daily VNS did not alter systemic arterial
blood pressure compared with FNS.
Conclusions—
VNS can reduce aneurysm rupture rates and improve the outcome from ruptured aneurysms.
No comments:
Post a Comment