http://nro.sagepub.com/content/21/5/448?etoc
A Kalinski,
R Sachdeva,
C Gomes,
SJ Lee,
Z Shah,
JD Houle
, and others. 2015. mRNAs and protein synthetic machinery localize into regenerating spinal cord axons when they are provided a substrate that
supports growth. J Neurosci 35(28):10357–70.
RB Perry,
M Fainzilber
. 2014. Local translation in neuronal processes-in vivo tests of a “heretical hypothesis”. Dev Neurobiol 74(3):210–7.
While it is well established that
ribosomes and mRNAs provide a substrate for protein synthesis within the
cell bodies of
neurons, there has been debate about whether
this biosynthetic machinery is present within the axons of mature
neurons. An
increasing number of studies have suggested that
growing axons exhibit the capacity for protein synthesis, and there is
evidence
that proteins are synthesized locally within
regenerating PNS axons where they provide a substrate for retrograde
signaling
and act locally as axons extend (Perry and
Fainzilber 2014). In contrast, less attention has been given to the
question of
whether mature CNS …
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