Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 1, 2026

The past, present and future of control architectures in lower-limb cable-driven robots for gait rehabilitation

 The only questions to be answered; DO THEY WORK FOR RECOVERY AND WHERE ARE THE PROTOCOLS? Not answering that is complete failure of this research!


The past, present and future of control architectures in lower-limb cable-driven robots for gait rehabilitation

We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

Due to their high power-to-weight ratio, modular and reconfigurable architectures, and inherent compliance, cable-driven rehabilitation robots (CDRRs) provide safe, lightweight, backdrivable solutions for gait and movement rehabilitation. However, they continue to face unique control challenges due to cable properties and user variability. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this systematic review explores control strategies for lower-limb CDRRs from the past decade. Out of the 968 studies initially identified, 70 met the selection criteria and were classified into six categories: position and velocity, force- and torque-based, compliance-based, model-based and optimal, learning-based and intention-informed, and hierarchical frameworks. Our analysis revealed a chronological evolution from traditional classical control toward more personalized, adaptive, learning-based, and intention-driven methods. Impedance and admittance control remain fundamental for ensuring safety, while newer approaches enable user-specific and environment-responsive assistance. This review proposes a unified hierarchical framework linking high-level intent detection to low-level actuation providing researchers and developers with a structured understanding of the control landscape for cable-driven lower-limb exoskeletons in healthcare and beyond. Control strategies were also linked to clinical outcomes to relate them to functional improvements across patient populations. Advancing CDRRs will require unified, multi-layer architectures that couple constraint-aware model-based control with adaptive and intention-driven learning to achieve safe, scalable, and clinically meaningful rehabilitation.

Hyperbaric oxygen therapy combined with computerized cognitive training improves global cognition and functional independence post-stroke: a randomized controlled trial

Why do HBOT when there are vastly simpler, cheaper and less risky ways to increase oxygen uptake?

 I can't see any use for HBOT unless it's delivered in the first week and there are vastly easier options for delivering oxygen than that.

Google this for risks: hyperbaric oxygen therapy deaths. 

Here are 43 posts on HBOT for your edification

Well, since this has been around for years why the hell doesn't someone actually do human testing and create protocols on stroke recovery?

Earlier research has this line:The drug, which is cheaply available for just $0.16 a day, works by boosting the number of oxygen molecules released into a cell, which in turn seems to benefit the robustness and longevity of the body’s basic building blocks. (This would seem to be much easier and faster than HBOT. I'm requesting this at my next stroke, my doctor won't know what hit her when I tell her how to treat me.)

If your doctor doesn't know about this s/he IS COMPLETELY FUCKING INCOMPETENT? And not creating protocols is even worse, allowing millions to billions of neurons to die because of lack of oxygen during the neuronal cascade of death!

 What other protocols is your doctor using to significantly improve oxygen delivery immediately post stroke? The first hours and days? NOTHING? Then you DON'T have a functioning stroke doctor, do you?

Maybe these, why isn't your incompetent doctor already delivering these to you?

cerebral blood flow (29 posts to July 2016)

Cerebral blood flow autoregulation (1 post to July 2021)

Cerebral Blood Flow Velocity (1 post to Febraury 2020)

cortical oxygenation (1 post to November 2020)

oxygen delivery (20 posts to January 2020)

oxygen uptake (5 posts to August 2013)

Normobaric oxygen (10 posts to January 2020)

  • brain blood flow (3 posts to April 2019)

  •  Oh, your incompetent doctor doesn't have any and doesn't fucking care about learning better ways to get you recovered! Well, fire them! PREDICTING DAMAGE DOES NOTHING!

    The latest here:

    Hyperbaric oxygen therapy combined with computerized cognitive training improves global cognition and functional independence post-stroke: a randomized controlled trial

    We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

    Abstract

    Background

    Post-stroke cognitive impairment (PSCI) is prevalent following stroke. Both hyperbaric oxygen therapy (HBOT) and cognitive training have demonstrated efficacy in the treatment of PSCI; however, it remains unclear whether combining HBOT with cognitive training has a synergistic effect on global cognition and functional independence in PSCI.

    Objective

    We aimed to investigate the effects of HBOT combined with computerized cognitive training (CCT) on global cognition and functional independence in patients with PSCI, and to explore associated neural correlates.

    Methods

    In this single-center, randomized controlled clinical trial, 116 patients with PSCI (39 ischemic, 77 hemorrhagic) were randomly assigned to four groups who received HBOT+standard treatment, CCT+standard treatment, combined HBOT + CCT+standard treatment, or standard treatment alone. All groups received 20 treatment sessions over 4 weeks (five sessions/week). Global cognition was assessed before and after treatment using the Mini-Mental State Examination (MMSE). Functional independence in basic activities of daily living (ADLs) was assessed using the Barthel Index (BI). Resting-state functional connectivity (FC) was assessed using functional near-infrared spectroscopy.

    Results

    Patients in the HBOT + CCT group showed significantly greater improvements in MMSE total scores, several MMSE subscores, including orientation, registration, attention, recall, and visuospatial, and BI scores, than the other groups (all ts(112) ≥ 2.74, all Bonferroni-corrected ps ≤ 0.043). Resting-state FC between the left dorsolateral prefrontal cortex and left pars triangularis of Broca’s area was significantly higher in the HBOT + CCT group than in the control group (t(111) = 2.93; Bonferroni-corrected p = 0.025). The change in FC was also significantly correlated with MMSE improvement (r(113) = 0.552, p < 0.001).

    Conclusion

    Combined HBOT and CCT may represent a beneficial intervention for patients with PSCI and could be associated with changes in global cognition, functional independence in basic ADLs, and prefrontal functional connectivity.

    Trial registration The study has been listed in the Chinese Clinical Trial Registry (ChiCTR2400080685).