http://onlinelibrary.wiley.com/doi/10.1002/gps.4353/abstract;jsessionid=D138F0CA16191A8D70229C57D294BEEA.f03t04
Article first published online: 7 SEP 2015
DOI: 10.1002/gps.4353
Copyright © 2015 John Wiley & Sons, Ltd.
Issue
International Journal of Geriatric Psychiatry
Additional Information(Show All)
- Abstract
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Keywords:
- post-stroke depression;
- minor stroke;
- ischemic stroke;
- quality of life;
- disability
Objective
Minor
stroke is characterized by mild neurological functional impairment and
relatively good outcome. Little is known about the association between
post-stroke depression (PSD) and outcomes of minor stroke. The aim of
this study was to investigate the association between PSD and disability
and quality of life (QoL) at 1 year after minor ischemic stroke.
Methods
Patients with first-ever minor ischemic stroke (n
= 747) were followed up at 14 ± 2 days, 3 months, 6 months, and 1 year
after stroke. Depressive symptoms were assessed at each follow-up.
Patients diagnosed with depression at 14 ± 2 days formed the early-onset
PSD group; those who were diagnosed with depression at any subsequent
follow-ups for the first time constituted the late-onset PSD group. The
outcomes of minor stroke including disability (modified Rankin score ≥2)
and QoL (Short Form-36 Health Survey) were assessed at the 1-year
follow-up.
Results
A
total of 198 (26.5%) patients were diagnosed with PSD over the 1-year
follow-up; 136 and 62 patients were allocated to the early-onset PSD
group and late-onset PSD group, respectively. Both early-onset and
late-onset PSD were independently associated with disability and poor
physical and mental health at 1 year after stroke. Recovery from
depression (n = 112) within 1 year decreased the adverse impacts of PSD on functional outcome and QoL.
Conclusions
Post-stroke
depression was independently associated with disability and poor QoL at
1 year after first-ever minor ischemic stroke. Recovery from PSD
decreased but did not eliminate the adverse impacts of PSD on outcomes
of minor stroke.
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