Deans' stroke musings: Nanoparticles show early promise in reducing inflammation after brain bleed

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 18, 2016

Nanoparticles show early promise in reducing inflammation after brain bleed

What is the difference in inflammation after bleeds vs. clots?
http://www.alphagalileo.org/ViewItem.aspx?ItemId=160779&CultureCode=en
Nanoparticles from ceria – a rare earth metal – might lessen inflammation in the brain following a bleeding stroke (hemorrhagic stroke), according to research presented at the American Stroke Association’s International Stroke Conference 2016.
Researchers from South Korea noted that previous studies have shown that ceria nanoparticles have strong antioxidant properties as well as anti-inflammatory effects. This study investigated whether the tiny particles could reduce inflammation that occurs just after an intracerebral hemorrhage (bleeding within the brain).
In a lab experiment, researchers studied a type of white blood cell called macrophages taken from the brains of rats and applied ceria nanoparticles to them. Compared with untreated macrophages, the macrophages treated with the nanoparticles secreted fewer inflammation-promoting chemicals.
In a second experiment, researchers injected ceria nanoparticles in 10 rats with brain bleeds. Compared with 10 untreated rats, the treated rats had less damage at the stroke site and less water accumulation, suggesting less inflammation in the area of the stroke, researchers said.

http://newsroom.heart.org/news/basic-science-tip-sheet-3127213?preview=288bf38a9020a77868a1001b3426486c

Full bibliographic informationPoster W P265 - Chi Kyung Kim, Dong-Wan Kang, In-Young Choi, Seul-Ki Ki, Seoul Natl Univ Hosp, Seoul, Korea, Republic of; Min Soh, Seoul Natl Univ, Seoul, Korea, Republic of; Do Yeon Kim, Jung Min Pyun, Han-Gil Jeong, Jun Yup Kim, Seung-Hoon Lee, Seoul Natl Univ Hosp, Seoul, Korea, Republic of
Anti-inflammatory Effects Of Ceria Nanoparticles In Experimental Intracerebral Hemorrhage Models
American Heart Association’s International Stroke Conference 2016, February 16-19, 2016, Los Angeles, California.