Can your doctors and hospital follow up this with research in humans? Or are they going to sit on their asses once again twiddling their thumbs?
https://www.theguardian.com/science/2018/sep/19/removing-faulty-brain-cells-staves-off-dementia-in-mice
Researchers say that when they swept away the senescent brain cells in mice, the outwards symptoms of their dementia vanished
Purging “zombie cells” from the brain could stave off the effects of dementia, a groundbreaking study has found.
The research in mice is the first to show that so-called senescent
cells, which enter a state of suspended animation as the body ages,
contribute to neurodegeneration. Flushing out these cells was shown to
prevent damage, potentially opening a new line of attack against
Alzheimer’s and other forms of dementia.
Prof Lawrence Rajendran, deputy director of the Dementia Research Institute at King’s College London who was not involved in the study, described the findings as “exciting”.
“It is not only novel in its approach but also opens up new vistas
for both diagnosis and therapy for neurodegenerative diseases, including
Alzheimer’s,” he said.
Initially senescent cells were thought to be inert bystanders –
useless, but harmless. However, in the past decade that picture has
changed as evidence has emerged linking senescent cells to Parkinson’s disease, diabetes, arthritis, heart disease and ageing itself. The latest study adds dementia to this list.
Writing in the journal Nature,
the researchers describe how mice with a genetic form of dementia
accumulated senescent cells in regions of the brain that are involved in
memory and cognition, such as the hippocampus. The mice had been
genetically engineered to produce a faulty version of the brain protein
tau, which was seen to build up in abnormal tangles as the mice lost the
ability to learn and remember new information.
However, when the mice were treated by administering a
genetically modified enzyme to sweep away senescent cells as they
appeared, the outward symptoms of dementia vanished.
Darren Baker, a molecular biologist at the Mayo Clinic in Minnesota
and senior author of the paper, said: “When senescent cells were
removed, we found that the diseased animals retained the ability to form
memories, eliminated signs of inflammation, did not develop [protein]
tangles, and had maintained normal brain mass.”
People with the same mutation develop dementia early in life and show
some of the hallmarks of Alzheimer’s disease. However, further work is
needed to test whether the findings translate into patients. “We
anticipate finding that senescent cells negatively impact brain health
in humans, but those experiments will be difficult to design and
perform,” said Baker.
The team also revealed the brain cells that became senescent were two
forms of immune cell in the brain, called microglia and astrocytes,
rather than neurons.
Baker said the team had not yet established why the senescent cells
cause problems, although previous work has suggested they secrete
inflammatory chemicals and cause other nearby cells to enter a
semi-dormant state too.
Scientists are also uncertain what happens when senescent cells are
removed from the brain – whether new brain cells would be generated or
whether over time the brain’s cell content would gradually shrink.
Dr James Pickett, head of research at Alzheimer’s Society, said:
“There hasn’t been a new dementia drug in 15 years so it’s exciting to
see the results of this promising study in mice. However, there are
several barriers to overcome before we can say if this is a safe,
effective treatment in people. For example, we don’t know if this drug
is actually able to enter the brain, and older people often have lots of
harmless brain cells that look like the senescent ‘zombie’ cells this
drug targets, so any treatment would have to be good at telling the two
apart.”
Rosa Sancho, head of research at Alzheimer’s Research UK, said:
“Researchers are continuing to build a clearer picture of the precise
interplay between the immune system and the brain, and this new work
adds another piece to this puzzle.”
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 27,951 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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