Ask your doctor if this treatment could vastly reduce your chances of getting another stroke or heart attack.
What other treatments does your doctor have you on to reduce
atherosclerosis? Any of these? Or is your doctor not treating your
vascular inflammation at all?
VIP-U: Psoriasis treatment reduces vascular inflammation Feb. 2018
Researchers develop new biomedical polymer to treat atherosclerosis May 2017
Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke Jan. 2017
Watermelon juice reverses hardening of the arteries Nov. 2011
New study shows aged garlic extract can reduce dangerous plaque buildup in arteries Jan. 2016
The latest here:
Anti-inflammatory psoriasis agents could prevent heart disease
Anti-inflammatory
biologic therapy for treatment of severe psoriasis reduced coronary
artery plaque, raising questions about whether such agents could have a
role in prevention of CHD, researchers reported in Cardiovascular Research.
“Classically a heart attack is caused by one of five risk factors: diabetes, hypertension, high cholesterol, family history or smoking,” Nehal N. Mehta, MD, chief of inflammation and cardiometabolic diseases at the NHLBI, said in a press release from the NIH. “Our study presents evidence that there is a sixth factor, inflammation; and that it is critical to both the development and the progression of atherosclerosis to heart attack.”
Mehta and colleagues conducted a prospective observational study of
121 patients with moderate to severe psoriasis and low risk for CVD
(mean age, 51 years; 58% men; median Framingham risk score, 3), who
completed 1-year follow-up and had not had biologic treatment at
baseline. During the study period, 89 patients were treated with
biologic therapy.
All patients underwent coronary CTA at baseline and 1 year to quantify total plaque coronary burden and plaque subcomponents in three coronary vessels of at least 2 mm in diameter.
According to the researchers, biologic therapy was associated with reductions in noncalcified plaque burden (6%; P = .005) and necrotic core (57%; P = .03), but not in fibrous burden (P = .71).
Compared with patients who were not treated with biologics, those who were had a greater decrease in noncalcified plaque burden (–0.07 mm2 vs. 0.06 mm2; P = .02), which persisted after adjustment for traditional CV risk factors (beta = 0.2; P = .02), Mehta and colleagues wrote.
The group treated with biologics had a reduction in C-reactive protein at 1 year (P < .001), but the untreated group did not (P = .21).
The treatment effect was greatest in patients treated with , according to the researchers.
“We found that these anti-inflammatory drugs commonly used to treat severe psoriasis also improve plaque in the coronary artery, making them more stable and less likely to cause a heart attack. This occurred in the absence of changes in traditional cardiovascular risk factors including blood pressure and blood lipids,” Mehta said in a press release from the European Society of Cardiology. “This preliminary study provides the first evidence that biologic therapy is associated with coronary plaque reduction and stabilization, and provides strong rationale for conduct of a randomized trial testing the impact of biologic therapy on the progression of coronary disease in patients with psoriasis.” – by Erik Swain
Disclosures: Mehta reports he received research grants to his employer, the NHLBI, from AbbVie, Celgene, Janssen and Novartis. Please see the study for all other authors’ relevant financial disclosures.
“Classically a heart attack is caused by one of five risk factors: diabetes, hypertension, high cholesterol, family history or smoking,” Nehal N. Mehta, MD, chief of inflammation and cardiometabolic diseases at the NHLBI, said in a press release from the NIH. “Our study presents evidence that there is a sixth factor, inflammation; and that it is critical to both the development and the progression of atherosclerosis to heart attack.”
All patients underwent coronary CTA at baseline and 1 year to quantify total plaque coronary burden and plaque subcomponents in three coronary vessels of at least 2 mm in diameter.
According to the researchers, biologic therapy was associated with reductions in noncalcified plaque burden (6%; P = .005) and necrotic core (57%; P = .03), but not in fibrous burden (P = .71).
Compared with patients who were not treated with biologics, those who were had a greater decrease in noncalcified plaque burden (–0.07 mm2 vs. 0.06 mm2; P = .02), which persisted after adjustment for traditional CV risk factors (beta = 0.2; P = .02), Mehta and colleagues wrote.
The group treated with biologics had a reduction in C-reactive protein at 1 year (P < .001), but the untreated group did not (P = .21).
The treatment effect was greatest in patients treated with , according to the researchers.
“We found that these anti-inflammatory drugs commonly used to treat severe psoriasis also improve plaque in the coronary artery, making them more stable and less likely to cause a heart attack. This occurred in the absence of changes in traditional cardiovascular risk factors including blood pressure and blood lipids,” Mehta said in a press release from the European Society of Cardiology. “This preliminary study provides the first evidence that biologic therapy is associated with coronary plaque reduction and stabilization, and provides strong rationale for conduct of a randomized trial testing the impact of biologic therapy on the progression of coronary disease in patients with psoriasis.” – by Erik Swain
Disclosures: Mehta reports he received research grants to his employer, the NHLBI, from AbbVie, Celgene, Janssen and Novartis. Please see the study for all other authors’ relevant financial disclosures.
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